MPL anticorps (Extracellular Domain)

N° du produit ABIN967682

Détail du produit anti-MPL anticorps

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Épitope: Extracellular Domain

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MPL est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Marque: BD Pharmingen™

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human c-Mpl extracellular domain

Clone: 1-78-1

Isotype: IgG1 kappa

Information d'application

Commentaires:

Related Products: ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-MPL (ABIN967682)

Abbott, Huang, Ellison, Chen, Arora, Szilvassy, Wei: "Mouse monoclonal antibodies against human c-Mpl and characterization for flow cytometry applications." dans: Hybridoma (2005), Vol. 29, Issue 2, pp. 103-13, (2010) (PubMed).

Deng, Banu, Malloy, Hass, Wang, Cavacini, Eaton, Avraham: "An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis." dans: Blood, Vol. 92, Issue 6, pp. 1981-8, (1998) (PubMed).

Gotoh, Ritchie, Takahira, Broxmeyer: "Thrombopoietin and erythropoietin activate inside-out signaling of integrin and enhance adhesion to immobilized fibronectin in human growth-factor-dependent hematopoietic cells." dans: Annals of hematology, Vol. 75, Issue 5-6, pp. 207-13, (1998) (PubMed).

Broudy, Lin, Fox, Taga, Saito, Kaushansky: "Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit." dans: Blood, Vol. 88, Issue 6, pp. 2026-32, (1996) (PubMed).

Détails sur MPL

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Autre désignation: CD110 (MPL Produits)

Synonymes: anticorps C-MPL, anticorps CD110, anticorps MPLV, anticorps THCYT2, anticorps TPOR, anticorps TPO-R, anticorps c-mpl, anticorps c-mpl-I, anticorps c-mpl-II, anticorps hlb219, anticorps MPL, anticorps mpll, anticorps tpor, anticorps tpor.b, anticorps MPL proto-oncogene, thrombopoietin receptor, anticorps myeloproliferative leukemia virus oncogene, anticorps MPL, anticorps Mpl, anticorps mpl

Sujet: The 1.78.1 monoclonal antibody specifically binds to the human Thrombopoietin Receptor (TPO-R) that is also know as the Myeloproliferative leukemia protein (c-Mpl) or CD110. CD110 is a type I transmembrane protein and a member of the hematopoietin receptor family. It is expressed on hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage and platelets. CD110 serves as a receptor for thrombopoietin. Upon binding of thrombopoietin to CD110, megakaryocyte proliferation and differentiation is induced and stem cells are protected from apoptosis.
Synonyms: C-MPL, MPL, MPLV, TPOR, Thrombopoietin receptor

Poids moléculaire: 65-72 kDa (HEL cells) and 80-90 kDa (Platelets)

Pathways: Signalistation JAK/STAT