Annexin A2 anticorps (AA 123-328)

N° du produit ABIN967722

Cité dans 5 publications. Cet anticorps anti-Annexin A2 Monoclonal Souris (Clone 5-Annexin II) (ABIN967722) détecte spécifiquement Annexin A2 dans WB, IF, IP et IHC (f). L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien et Poulet.

Aperçu rapide pour Annexin A2 anticorps (AA 123-328) (ABIN967722)

Antigène: Annexin A2 (ANXA2)

Reactivité: Humain, Souris, Rat, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Annexin A2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: 5-Annexin II

Détail du produit anti-Annexin A2 anticorps

Épitope: AA 123-328

Réactivité croisée: Poulet, Chien, Souris, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Annexin II aa. 123-328

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968533, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-Annexin A2 (ABIN967722)

Hansen, Ehrlich, Nelson: "Molecular mechanism for orienting membrane and actin dynamics to nascent cell-cell contacts in epithelial cells." dans: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45371-6, (2002) (PubMed).

Kwon, Caplan, Filipenko, Choi, Fitzpatrick, Zhang, Waisman: "Identification of annexin II heterotetramer as a plasmin reductase." dans: The Journal of biological chemistry, Vol. 277, Issue 13, pp. 10903-11, (2002) (PubMed).

Choi, Fitzpatrick, Filipenko, Fogg, Kassam, Magliocco, Waisman: "Regulation of plasmin-dependent fibrin clot lysis by annexin II heterotetramer." dans: The Journal of biological chemistry, Vol. 276, Issue 27, pp. 25212-21, (2001) (PubMed).

Jacovina, Zhong, Khazanova, Lev, Deora, Hajjar: "Neuritogenesis and the nerve growth factor-induced differentiation of PC-12 cells requires annexin II-mediated plasmin generation." dans: The Journal of biological chemistry, Vol. 276, Issue 52, pp. 49350-8, (2001) (PubMed).

Chasserot-Golaz, Vitale, Sagot, Delouche, Dirrig, Pradel, Henry, Aunis, Bader: "Annexin II in exocytosis: catecholamine secretion requires the translocation of p36 to the subplasmalemmal region in chromaffin cells." dans: The Journal of cell biology, Vol. 133, Issue 6, pp. 1217-36, (1996) (PubMed).

Détails sur Annexin A2

Antigène: Annexin A2 (ANXA2)

Autre désignation: Annexin II

Sujet: Annexin II (p36), originally discovered as a substrate for the src oncogene, is one of the most studied members of the annexin family of calcium-dependent phospholipid-binding proteins. It exists in cells as either a monomer or a heterotetramer complexed with p11, an S100-related protein. In vitro, it has been found that unphosphorylated annexin II is capable of causing aggregation of chromaffin granules, and, upon phosphorylation, induces fusion of the granules' membranes. A similiar phenomenon may occur in the final steps of exocytosis after cytoplasmic annexin translocates to the subplasmalemmal region and is phosphorylated by protein kinase C. However, other studies refute annexin II's involvement in exocytosis, and a conclusive role for annexin II in membrane trafficking remains debated. This antibody is routinely tested by western blot analysis.
Synonyms: Lipocortin II, Calpactin I

Poids moléculaire: 36 kDa

Pathways: S100 Proteins