Annexin A2 anticorps (AA 1-97)

N° du produit ABIN967723

Cet anticorps Souris Monoclonal détecte spécifiquement Annexin A2 dans WB, IHC, IF et IP. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Chien et Poulet. Il a été cité dans 5+ publications.

Aperçu rapide pour Annexin A2 anticorps (AA 1-97) (ABIN967723)

Antigène: Annexin A2 (ANXA2)

Reactivité: Humain, Souris, Rat, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Annexin A2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 148-Annexin II Light Chain

Détail du produit anti-Annexin A2 anticorps

Épitope: AA 1-97

Réactivité croisée: Chien, Poulet, Humain

Aucune reactivité croisée: Rat (Rattus), Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Cow Annexin II Light Chain aa. 1-97

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968536

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-Annexin A2 (ABIN967723)

Huang, Pawliczak, Cowan, Gladwin, Madara, Logun, Shelhamer: "Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid release in human epithelial cells." dans: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38431-40, (2002) (PubMed).

Kwon, Caplan, Filipenko, Choi, Fitzpatrick, Zhang, Waisman: "Identification of annexin II heterotetramer as a plasmin reductase." dans: The Journal of biological chemistry, Vol. 277, Issue 13, pp. 10903-11, (2002) (PubMed).

Choi, Fitzpatrick, Filipenko, Fogg, Kassam, Magliocco, Waisman: "Regulation of plasmin-dependent fibrin clot lysis by annexin II heterotetramer." dans: The Journal of biological chemistry, Vol. 276, Issue 27, pp. 25212-21, (2001) (PubMed).

Harder, Kellner, Parton, Gruenberg: "Specific release of membrane-bound annexin II and cortical cytoskeletal elements by sequestration of membrane cholesterol." dans: Molecular biology of the cell, Vol. 8, Issue 3, pp. 533-45, (1997) (PubMed).

Regnouf, Sagot, Delouche, Devilliers, Cartaud, Henry, Pradel: ""In vitro" phosphorylation of annexin 2 heterotetramer by protein kinase C. Comparative properties of the unphosphorylated and phosphorylated annexin 2 on the aggregation and fusion of chromaffin granule membranes." dans: The Journal of biological chemistry, Vol. 270, Issue 45, pp. 27143-50, (1995) (PubMed).

Détails sur Annexin A2

Antigène: Annexin A2 (ANXA2)

Autre désignation: Annexin II

Sujet: Annexin II often exists as a heterotetramer complexed with an 11kDa light chain. This p11 subunit is related to the S100 family of calcium-binding proteins but mutations have rendered it unable to bind calcium. The p11 protein binds to the amino terminus of the annexin II monomer, but not to other annexins. It may regulate the function of annexin II, as the tetrameric form seems to have a higher calcium and phospholipid-binding affinity than the monomeric annexin II. In the cell, p11 has been localized to the cytoplasmic face of the plasma membrane where the annexin II tetramer is known to exist.

Poids moléculaire: 11 kDa

Pathways: S100 Proteins