CAN anticorps (AA 247-449)

N° du produit ABIN967861

Cet anticorps Souris Monoclonal détecte spécifiquement CAN dans WB, IHC, IP et IF. Il présente une réactivité envers Humain, Souris, Rat, Poulet et Grenouille et a été mentionné dans 5+ publications.

Aperçu rapide pour CAN anticorps (AA 247-449) (ABIN967861)

Antigène: CAN (Calcineurin (CAN))

Reactivité: Humain, Souris, Rat, Poulet, Grenouille

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CAN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: 29-Calcineurin

Détail du produit anti-CAN anticorps

Épitope: AA 247-449

Réactivité croisée: Rat (Rattus), Souris, Poulet, Grenouille

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Calcineurin aa. 247-449

Isotype: IgG2a

Information d'application

Commentaires:

Related Products: ABIN968545, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-CAN (ABIN967861)

Vega, Rothermel, Weinheimer, Kovacs, Naseem, Bassel-Duby, Williams, Olson: "Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 2, pp. 669-74, (2003) (PubMed).

Jicha, Weaver, Lane, Vianna, Kress, Rockwood, Davies: "cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 17, pp. 7486-94, (1999) (PubMed).

Liang, Venema, Wang, Ju, Venema, Marrero: "Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells." dans: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 19846-51, (1999) (PubMed).

Sík, Hájos, Gulácsi, Mody, Freund: "The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 6, pp. 3245-50, (1998) (PubMed).

Verin, Cooke, Herenyiova, Patterson, Garcia: "Role of Ca2+/calmodulin-dependent phosphatase 2B in thrombin-induced endothelial cell contractile responses." dans: The American journal of physiology, Vol. 275, Issue 4 Pt 1, pp. L788-99, (1998) (PubMed).

Détails sur CAN

Antigène: CAN (Calcineurin (CAN))

Autre désignation: Calcineurin

Sujet: Calcineurin is a Ca2+/calmodulin-dependent protein phosphatase. The active enzyme is a heterodimer of a large calmodulin-binding catalytic subunit A (61 kDa) and a smaller Ca2+ binding subunit B (19 kDa). Regions corresponding to the calmodulin-binding site, an autoinhibitory domain, and a putative subunit B binding site have been identified within the large subunit A. The activity of calcineurin is sensitive to immunosuppressants such as cyclosporin A (CsA) and tacrolimus (FK506). The study of FK506-mediated inhibition of nitric oxide formation has revealed that nitric oxide synthase (NOS) is a calcineurin substrate. Calcineurin dephosphorylates NOS and enhances its catalytic activity. Therefore, Calcineurin is an essential mediator for efficient T cell antigen receptor (TCR)-mediated T cell activation.

Poids moléculaire: 61 kDa