AKAP5 anticorps (AA 180-427)

N° du produit ABIN967900

Cet anticorps Souris Monoclonal détecte spécifiquement AKAP5 dans WB, IHC, IF et IP. Il présente une réactivité envers Humain et a été mentionné dans 4+ publications.

Aperçu rapide pour AKAP5 anticorps (AA 180-427) (ABIN967900)

Antigène: AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp AKAP5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 22-AKAP79

Détail du produit anti-AKAP5 anticorps

Épitope: AA 180-427

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human AKAP79 aa. 180-427

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968552, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-AKAP5 (ABIN967900)

Schillace, Andrews, Liberty, Davey, Carr: "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 4, pp. 1590-9, (2002) (PubMed).

Jicha, Weaver, Lane, Vianna, Kress, Rockwood, Davies: "cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 17, pp. 7486-94, (1999) (PubMed).

Coghlan, Perrino, Howard, Langeberg, Hicks, Gallatin, Scott: "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein." dans: Science (New York, N.Y.), Vol. 267, Issue 5194, pp. 108-11, (1995) (PubMed).

Carr, Stofko-Hahn, Fraser, Cone, Scott: "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79." dans: The Journal of biological chemistry, Vol. 267, Issue 24, pp. 16816-23, (1992) (PubMed).

Détails sur AKAP5

Antigène: AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))

Autre désignation: AKAP79

Sujet: The type II cAMP-dependent Protein Kinase (PKA) is compartmentalized within the cell. To maintain this localization of type II PKAs, the regulatory subunit (RII) interacts with specific RII-anchoring proteins. For instance, attachment of type II PKA to the cytoskeleton occurs through the binding of RII to microtubule-associated protein 2 (MAP2). In brain, several proteins have been identified as PKA type II anchoring proteins and form a family named AKAP (A-Kinase Anchor Proteins). AKAP79 is a 79kDa human RII-anchoring protein. AKAP, PKA type II, and calcineurin (PP2B) can form a tertiary complex, suggesting that both PKA and calcineurin are targeted by a common protein to subcellular sites where they regulate the phosphorylation status of key substrates.

Poids moléculaire: 79 kDa

Pathways: cAMP Metabolic Process