CK1 epsilon anticorps (AA 248-414)

N° du produit ABIN967975

Cet anticorps Souris Monoclonal détecte spécifiquement CK1 epsilon dans WB, IHC, IF et IP. Il présente une réactivité envers Humain, Souris, Rat, Chien et Poulet et a été mentionné dans 4+ publications.

Aperçu rapide pour CK1 epsilon anticorps (AA 248-414) (ABIN967975)

Antigène: CK1 epsilon (CSNK1E) (Casein Kinase 1, epsilon (CSNK1E))

Reactivité: Humain, Souris, Rat, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CK1 epsilon est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 1-Casein Kinase Iepsilon

Détail du produit anti-CK1 epsilon anticorps

Épitope: AA 248-414

Réactivité croisée: Souris, Rat (Rattus), Poulet, Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Casein Kinase Iepsilon aa. 248-414

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-CK1 epsilon (ABIN967975)

Akashi, Tsuchiya, Yoshino, Nishida: "Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells." dans: Molecular and cellular biology, Vol. 22, Issue 6, pp. 1693-703, (2002) (PubMed).

Kishida, Hino Si, Michiue, Yamamoto, Kishida, Fukui, Asashima, Kikuchi: "Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon." dans: The Journal of biological chemistry, Vol. 276, Issue 35, pp. 33147-55, (2001) (PubMed).

Peters, McKay, McKay, Graff: "Casein kinase I transduces Wnt signals." dans: Nature, Vol. 401, Issue 6751, pp. 345-50, (1999) (PubMed).

Fish, Cegielska, Getman, Landes, Virshup: "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family." dans: The Journal of biological chemistry, Vol. 270, Issue 25, pp. 14875-83, (1995) (PubMed).

Détails sur CK1 epsilon

Antigène: CK1 epsilon (CSNK1E) (Casein Kinase 1, epsilon (CSNK1E))

Autre désignation: Casein Kinase Iepsilon

Sujet: Casein Kinase Iepsilon (CKIepsilon) is a product of a family of proteins involved in the regulation of various cytoplasmic and nuclear processes including DNA replication and repair. CKIepsilon is a 47.3 kDa serine/threonine kinase that plays a role similar to previously described CKI isoforms. It phosphorylates known CKI substrates, including a CKI-specific peptide. In addition, it is inhibited by CKI-7, an inhibitor of other CKI isoforms. CKIepsilon contains a core kinase domain of 285 amino acids which is 53-98% identical to other isoforms and is most similiar in structure to CKIdelta. Since various human and yeast CKI proteins exhibit both sequence and functional similarities, CKIepsilon may be involved in mammalian DNA metabolism.

Poids moléculaire: 47 kDa

Pathways: Signalisation Hedgehog, M Phase