EPH Receptor A4 anticorps (AA 279-472)

N° du produit ABIN967994

L’anticorps Souris Monoclonal anti-EPH Receptor A4 a été validé pour WB, IHC, IF et IP. Il convient pour détecter EPH Receptor A4 dans des échantillons de Humain, Souris, Rat, Chien et Poulet. Il y a 3+ publications disponibles.

Aperçu rapide pour EPH Receptor A4 anticorps (AA 279-472) (ABIN967994)

Antigène: EPH Receptor A4 (EPHA4)

Reactivité: Humain, Souris, Rat, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EPH Receptor A4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 35-EphA4

Détail du produit anti-EPH Receptor A4 anticorps

Épitope: AA 279-472

Réactivité croisée: Rat (Rattus), Humain, Chien, Poulet

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse Sek aa. 279-472

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968545

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-EPH Receptor A4 (ABIN967994)

Ellis, Kasmi, Ganju, Walls, Panayotou, Reith: "A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn." dans: Oncogene, Vol. 12, Issue 8, pp. 1727-36, (1996) (PubMed).

Becker, Gilardi-Hebenstreit, Seitanidou, Wilkinson, Charnay: "Characterisation of the Sek-1 receptor tyrosine kinase." dans: FEBS letters, Vol. 368, Issue 2, pp. 353-7, (1995) (PubMed).

Gilardi-Hebenstreit, Nieto, Frain, Mattéi, Chestier, Wilkinson, Charnay: "An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain." dans: Oncogene, Vol. 7, Issue 12, pp. 2499-506, (1993) (PubMed).

Détails sur EPH Receptor A4

Antigène: EPH Receptor A4 (EPHA4)

Autre désignation: EphA4

Sujet: EphA4/Sek is a glycosylated protein tyrosine kinase of 986 amino acids and an apparent 110-130kDa molecular weight (molecular weight depends on glycocylation level of protein). EphA4 belongs to the Eph subfamily of receptor tyrosine kinases and like many others, it has an amino-terminal ligand-binding domain exposed to the extracellar matrix. EphA4 is predominantly expressed during development (this is common in the Eph family) and because of its mRNA localization, it has been proposed that it may play a role during segmentation of the hindbrain and mesoderm. Tyrosine 602 is a major autophosphorylation site of EphA4 and appears to be the docking site for the intracellular tyrosine kinase fyn.

Poids moléculaire: 110-130 kDa

Pathways: Signalisation RTK