BCL2L1 anticorps (AA 18-233)

N° du produit ABIN968152

Cet anticorps Souris Monoclonal détecte spécifiquement BCL2L1 dans WB, IHC, IF et IP. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 5+ publications.

Aperçu rapide pour BCL2L1 anticorps (AA 18-233) (ABIN968152)

Antigène: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCL2L1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 44-Bcl

Détail du produit anti-BCL2L1 anticorps

Épitope: AA 18-233

Réactivité croisée: Souris, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Bcl-xl aa. 18-233

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-BCL2L1 (ABIN968152)

Devarajan, De Leon, Talasazan, Schoenfeld, Davidowitz, Burk: "The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways." dans: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40599-605, (2001) (PubMed).

Oetzel, Jonuleit, Götz, van der Kuip, Michels, Duyster, Hallek, Aulitzky: "The tyrosine kinase inhibitor CGP 57148 (ST1 571) induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 5, pp. 1958-68, (2000) (PubMed).

Soini, Kinnula, Kaarteenaho-Wiik, Kurttila, Linnainmaa, Pääkkö: "Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant mesothelioma." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 5, Issue 11, pp. 3508-15, (2000) (PubMed).

Kishimoto, Sprent: "Strong TCR ligation without costimulation causes rapid onset of Fas-dependent apoptosis of naive murine CD4+ T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 4, pp. 1817-26, (1999) (PubMed).

Anderson, Teutsch, Dong, Wortis: "An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 20, pp. 10966-71, (1996) (PubMed).

Détails sur BCL2L1

Antigène: BCL2L1 (BCL2-Like 1 (BCL2L1))

Autre désignation: Bcl-x

Sujet: Bcl-x is related to the Bcl-2 protein and can function independently of Bcl-2 in regulating apoptosis (programmed cell death). The bcl-x transcript is expressed in a number of tissues, with the highest levels in the lymphoid and central nervous systems. Two distinct cDNA species, bcl-xL and bcl-xS, have been observed and appear to arise from alternate 5' splice sites located within the first coding exon of the bcl-x gene. Bcl-xL is composed of 233 amino acids and is similar in size and structure to Bcl-2. The Bcl-xS polypeptide shows a deletion of 63 amino acids which consist of the region of Bcl-xL with the highest degree of amino acid identity to Bcl-2. Like Bcl-2, Bcl-xL inhibits cell death upon growth factor withdrawal when transfected into an IL-3-dependent cell line. However, Bcl-xS inhibits Bcl-2 mediated cell survival.

Poids moléculaire: 26 kDa

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling