XIAP anticorps (AA 268-426)

N° du produit ABIN968163

Cet anticorps anti-XIAP est un anticorps Souris Monoclonal détectant XIAP dans WB, IHC, IF et IP. Adapté pour Humain, Souris, Rat et Grenouille. Ce Primary Antibody a été cité dans 6+ publications.

Aperçu rapide pour XIAP anticorps (AA 268-426) (ABIN968163)

Antigène: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Reactivité: Humain, Souris, Rat, Grenouille

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp XIAP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 48-hILP-XIAP

Détail du produit anti-XIAP anticorps

Épitope: AA 268-426

Réactivité croisée: Rat (Rattus), Souris, Grenouille

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human hILP aa. 268-426

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968537, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-XIAP (ABIN968163)

Martin, Liu, Chen, Price, Pan, Swaby, Golden: "Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death." dans: The Journal of comparative neurology, Vol. 500, Issue 1, pp. 20-46, (2006) (PubMed).

Deng, Lin, Wu: "TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO." dans: Genes & development, Vol. 16, Issue 1, pp. 33-45, (2002) (PubMed).

Martins, Iaccarino, Tenev, Gschmeissner, Totty, Lemoine, Savopoulos, Gray, Creasy, Dingwall, Downward: "The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif." dans: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 439-44, (2002) (PubMed).

Fulda, Meyer, Debatin: "Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression." dans: Cancer research, Vol. 60, Issue 14, pp. 3947-56, (2000) (PubMed).

Tamm, Kornblau, Segall, Krajewski, Welsh, Kitada, Scudiero, Tudor, Qui, Monks, Andreeff, Reed: "Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 5, pp. 1796-803, (2000) (PubMed).

Duckett, Nava, Gedrich, Clem, Van Dongen, Gilfillan, Shiels, Hardwick, Thompson: "A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors." dans: The EMBO journal, Vol. 15, Issue 11, pp. 2685-94, (1996) (PubMed).

Détails sur XIAP

Antigène: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Autre désignation: hILP

Sujet: Apoptosis is a genetically programmed, selective process of cell death that occurs during normal cell differentiation and development of multicellular organisms. Viruses depend on the biosynthetic machinery of their host cell for the production of progeny and survival. Therefore, many viruses encode proteins that protect the cell from apoptosis. hILP (human IAP-like protein) is a human homologue of the viral IAP (Inhibitor of Apoptosis Protein). hILP is a widely expressed cytoplasmic protein of 497 amino acids with three BIR (Baculovirus IAP repeats) domains and a C-terminal RING finger domain. hILP-transfected cells are protected against the apoptotic effects of Sindbis virus infection and ICE (interleukin-1beta converting enzyme) expression. This product is sold under license from Aegera Therapeutics, Inc. This antibody is routinely tested by western blot analysis.
Synonyms: hILP

Poids moléculaire: 57 kDa

Pathways: Apoptose, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis