Plakophilin 2 anticorps (AA 19-183)

N° du produit ABIN968178

Détail du produit anti-Plakophilin 2 anticorps

Antigène: Plakophilin 2 (PKP2)

Épitope: AA 19-183

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Plakophilin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Plakophilin 2a aa. 19-183

Clone: 28-Plakophilin

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968587, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-Plakophilin 2 (ABIN968178)

Mertens, Kuhn, Franke: "Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque." dans: The Journal of cell biology, Vol. 135, Issue 4, pp. 1009-25, (1997) (PubMed).

Détails sur Plakophilin 2

Antigène: Plakophilin 2 (PKP2)

Autre désignation: Plakophilin 2 (PKP2 Produits)

Synonymes: anticorps ARVD9, anticorps 1200008D14Rik, anticorps 1200012P04Rik, anticorps AA516617, anticorps Pkp2l, anticorps plakophilin 2, anticorps PKP2, anticorps Pkp2

Sujet: Plakophilin 2 is a desmosomal plaque protein that belongs to the arm repeat family of proteins. Alternative splicing results in two isoforms: 2a (837 aa) and 2b (881 aa). The 2b isoform contains an insertion of 44 aa in the arm repeat unit 2. Other arm family members are ß-catenin, plakophilin 1, plakoglobin, pp120, and armadillo of Drosophila gene product. They have at least 9 repeats of the arm motif, which consists of approximately 42 aa, and a short carboxyl terminus. Plakophilins are constitutively expressed in desmosome-containing cells. Plakophilin 1 has been found only in desmosomal-containing cells, such as stratified and complex epithelia. Plakophilin 2 has been isolated from both desmosomal as well as non-desmosomal forming cells, including simple and glandular epithelia, and from nonepithelial tissues such as the mycocardium and Purkinje fibers. In addition, Plakophilin 2 is found in the karyoplasm of interphase cells. Plakophilins 2a and 2b are part of desmosomal plaques, although they are located primarily in the karyoplasm of the interphase nucleus. The function of nuclear plakophilin 2 remains to be identified.

Poids moléculaire: 100 kDa

Pathways: Cell-Cell Junction Organization, SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2