BCAN anticorps (AA 232-394)

N° du produit ABIN968235

Cet anticorps anti-BCAN est un anticorps Souris Monoclonal détectant BCAN dans WB et IF. Adapté pour Souris, Rat et Chien. Ce Primary Antibody a été cité dans 3+ publications.

Aperçu rapide pour BCAN anticorps (AA 232-394) (ABIN968235)

Antigène: BCAN (Brevican (BCAN))

Reactivité: Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCAN est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 2-Brevican

Détail du produit anti-BCAN anticorps

Épitope: AA 232-394

Réactivité croisée: Souris, Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Rat Brevican aa. 232-394

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968545, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-BCAN (ABIN968235)

Aspberg, Miura, Bourdoulous, Shimonaka, Heinegârd, Schachner, Ruoslahti, Yamaguchi: "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 19, pp. 10116-21, (1997) (PubMed).

Seidenbecher, Richter, Rauch, Fässler, Garner, Gundelfinger: "Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms." dans: The Journal of biological chemistry, Vol. 270, Issue 45, pp. 27206-12, (1995) (PubMed).

Yamada, Watanabe, Shimonaka, Yamaguchi: "Molecular cloning of brevican, a novel brain proteoglycan of the aggrecan/versican family." dans: The Journal of biological chemistry, Vol. 269, Issue 13, pp. 10119-26, (1994) (PubMed).

Détails sur BCAN

Antigène: BCAN (Brevican (BCAN))

Autre désignation: Brevican

Sujet: Neural tissue expresses a variety of cell surface heparan sulfate and extracellular chondroitin sulfate containing proteoglycans. Brevican, a chondroitin sulfate proteoglycan, is a member of the lectican family. Other members of this family are aggrecan, versican, and neurocan. These proteins are either heparan sulfate or keratan sulfate containing glycosylphosphatidylinositol (GPI) anchored or membrane spanning proteoglycans, or soluble chondroitin sulfate containing proteoglycans. Brevican exists as either a soluble or GPI-anchored plasma membrane protein. Brevican contains the shortest core protein of any of the family members. In addition, it is characterized by chondroitin sulfate chains, an N-terminal hyaluronic acid-binding domain (HA), an epidermal growth factor-like (EGF) repeat, and lectin-like and complement regulatory protein-like domains in its C-terminal region. Primary cerebellar astrocytes are the major site for mRNA expression and little, if any, is found in neurons. Although there is an 80 kDa N-terminal truncated form, full length brevican can be up to 145 kDa. Brevican is thought to play a role in the terminal differentiation and regulation of the adult nervous system. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 140-145 kDa

Pathways: Glycosaminoglycan Metabolic Process