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MSH6 anticorps (AA 225-333)

MSH6 Reactivité: Humain, Souris, Rat, Chien WB, IF Hôte: Souris Monoclonal 44-MSH6 unconjugated
N° du produit ABIN968247
  • Antigène Voir toutes MSH6 Anticorps
    MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
    Épitope
    • 15
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 225-333
    Reactivité
    • 80
    • 36
    • 30
    • 9
    • 4
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien
    Hôte
    • 59
    • 18
    • 3
    Souris
    Clonalité
    • 46
    • 34
    Monoclonal
    Conjugué
    • 48
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MSH6 est non-conjugé
    Application
    • 55
    • 27
    • 25
    • 22
    • 14
    • 13
    • 12
    • 8
    • 8
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Chien, Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human MSH6 aa. 225-333
    Clone
    44-MSH6
    Isotype
    IgG1
    Top Product
    Discover our top product MSH6 Anticorps primaire
  • Commentaires

    Related Products: ABIN968533, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Kariola, Otway, Lönnqvist, Raevaara, Macrae, Vos, Kohonen-Corish, Hofstra, Nyström-Lahti: "Two mismatch repair gene mutations found in a colon cancer patient--which one is pathogenic?" dans: Human genetics, Vol. 112, Issue 2, pp. 105-9, (2003) (PubMed).

    Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." dans: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).

    Humbert, Hermine, Hernandez, Bouget, Selves, Laurent, Salles, Lautier: "Implication of protein kinase C in the regulation of DNA mismatch repair protein expression and function." dans: The Journal of biological chemistry, Vol. 277, Issue 20, pp. 18061-8, (2002) (PubMed).

    Christmann, Kaina: "Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents." dans: The Journal of biological chemistry, Vol. 275, Issue 46, pp. 36256-62, (2000) (PubMed).

    Palombo, Gallinari, Iaccarino, Lettieri, Hughes, DArrigo, Truong, Hsuan, Jiricny: "GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells." dans: Science (New York, N.Y.), Vol. 268, Issue 5219, pp. 1912-4, (1995) (PubMed).

  • Antigène
    MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
    Autre désignation
    MSH6 (MSH6 Produits)
    Synonymes
    anticorps GTBP, anticorps GTMBP, anticorps HNPCC5, anticorps HSAP, anticorps p160, anticorps cb326, anticorps wu:fb36c12, anticorps LOC100227810, anticorps AU044881, anticorps AW550279, anticorps Gtmbp, anticorps mutS homolog 6, anticorps mutS homolog 6 (E. coli), anticorps DNA mismatch repair protein, anticorps MSH6, anticorps msh6, anticorps Msh6
    Sujet
    DNA mismatch repair in bacteria is carried out by the MutL, MutH, and MutS proteins. Initial binding of MutS to the mismatched DNA is followed by binding of the MutH endonuclease and MutL. Together these proteins form a complex that mediates excision repair. Mutations or deficiencies of any of these bacterial proteins results in a mutator phenotype that is characterized by genetic instability. MSH2, MSH3, and MSH6 are human homologs of MutS, while MLH1, PMS1, and PMS2 are homologs of MutL. As a heterodimer with MSH2, MSH6 binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes single-base mispairs and insertion/deletion loops. Binding of this complex induces conformational changes in the DNA that lead to the binding of an MLH-PMS1 complex and excision repair. Mutations in the human genes are associated with hereditary nonpolyposis colon cancer (HNPCC), a common hereditary disease in humans. HNPCC is characterized by frequent microsatellite mutations that arise from somatic mutation due to a replication error (RER+) phenotype. This phenotype is analogous to the bacterial system and is directly linked to DNA mismatch repair deficiencies.
    Synonyms: GTBP
    Poids moléculaire
    160 kDa
    Pathways
    Réparation de l'ADN, Chromatin Binding, Production of Molecular Mediator of Immune Response
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