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P4HB anticorps (AA 109-214)

P4HB Reactivité: Humain, Souris, Rat, Chien WB, IF Hôte: Souris Monoclonal 34-PDI unconjugated
N° du produit ABIN968267
  • Antigène Voir toutes P4HB Anticorps
    P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
    Épitope
    • 21
    • 19
    • 15
    • 13
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 109-214
    Reactivité
    • 107
    • 74
    • 65
    • 23
    • 22
    • 21
    • 20
    • 18
    • 18
    • 16
    • 10
    • 10
    • 8
    • 7
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien
    Hôte
    • 118
    • 26
    • 2
    Souris
    Clonalité
    • 109
    • 37
    Monoclonal
    Conjugué
    • 62
    • 16
    • 15
    • 9
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp P4HB est non-conjugé
    Application
    • 112
    • 68
    • 45
    • 44
    • 43
    • 36
    • 18
    • 15
    • 14
    • 13
    • 13
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Humain, Chien, Rat (Rattus), Souris
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Bovine PDI aa. 109-214
    Clone
    34-PDI
    Isotype
    IgG1
    Top Product
    Discover our top product P4HB Anticorps primaire
  • Commentaires

    Related Products: ABIN968551, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Jenne, Frey, Brugger, Wieland: "Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway." dans: The Journal of biological chemistry, Vol. 277, Issue 48, pp. 46504-11, (2002) (PubMed).

    Schlegel, Arvan, Lisanti: "Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum." dans: The Journal of biological chemistry, Vol. 276, Issue 6, pp. 4398-408, (2001) (PubMed).

    Weissman, Kim: "Efficient catalysis of disulphide bond rearrangements by protein disulphide isomerase." dans: Nature, Vol. 365, Issue 6442, pp. 185-8, (1993) (PubMed).

    Wetterau, Combs, Spinner, Joiner: "Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex." dans: The Journal of biological chemistry, Vol. 265, Issue 17, pp. 9800-7, (1990) (PubMed).

    Yamauchi, Yamamoto, Hayashi, Koya, Takikawa, Toyoshima, Horiuchi: "Sequence of membrane-associated thyroid hormone binding protein from bovine liver: its identity with protein disulphide isomerase." dans: Biochemical and biophysical research communications, Vol. 146, Issue 3, pp. 1485-92, (1987) (PubMed).

  • Antigène
    P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
    Autre désignation
    PDI (P4HB Produits)
    Synonymes
    anticorps DSI, anticorps ERBA2L, anticorps GIT, anticorps P4Hbeta, anticorps PDI, anticorps PDIA1, anticorps PHDB, anticorps PO4DB, anticorps PO4HB, anticorps PROHB, anticorps PDA2, anticorps PDIP, anticorps PDIR, anticorps ERp59, anticorps Pdia1, anticorps Thbp, anticorps p55, anticorps XPDIp, anticorps pdi, anticorps 1810041F13Rik, anticorps AI661267, anticorps Pdip, anticorps Pdipl, anticorps p58, anticorps prolyl 4-hydroxylase subunit beta, anticorps protein disulfide isomerase family A member 2, anticorps prolyl 4-hydroxylase, beta polypeptide, anticorps protein disulfide isomerase family A member 2 L homeolog, anticorps protein disulfide isomerase associated 2, anticorps prolyl 4-hydroxylase subunit beta L homeolog, anticorps protein disulfide-isomerase, anticorps P4HB, anticorps PDIA2, anticorps P4hb, anticorps pdia2.L, anticorps Pdia2, anticorps p4hb.L, anticorps LOC8281065
    Sujet
    The ER is the site of translation of membrane and secretory proteins. Following synthesis, it shuttles these proteins through a contiguous membrane system to their appropriate destinations. Protein disulfide isomerase (PDI) is an abundant, multifunctional, eukaryotic protein. Although it exhibits ubiquitous expression, it is primarily located in the ER lumen. Here, it functions to catalyze the isomerization of intramolecular disulfide bridges, thereby allowing them to generate their most thermodynamically stable configurations. This role in rearrangement has lead to the classification of PDI as a chaperone. Although protein folding occurs in its absence, PDI may be essential for it to proceed at a physiological relevant rate. In addition, PDI is the beta-subunit of prolyl 4- hydroxylase and is a component of the triglyceride transfer complex. PDI is retained in the ER lumen via its C-terminal -KDEL sequence. Via this sequence, it is continuously recycled back to the ER from other membranous compartments. Thus, PDI is a diverse protein whose primary function may be to correct disulfide bonding and, thus, ensure the most stable conformation of newly synthesized proteins.
    Poids moléculaire
    55 kDa
    Pathways
    Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism
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