Fatty Acid Synthase anticorps (AA 9-202)

N° du produit ABIN968279

L’anticorps Souris Monoclonal anti-Fatty Acid Synthase a été validé pour WB et IF. Il convient pour détecter Fatty Acid Synthase dans des échantillons de Humain, Souris, Rat, Lapin et Chien. Il y a 3+ publications disponibles.

Aperçu rapide pour Fatty Acid Synthase anticorps (AA 9-202) (ABIN968279)

Antigène: Fatty Acid Synthase (FASN)

Reactivité: Humain, Souris, Rat, Lapin, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fatty Acid Synthase est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 23-Fatty Acid Synthase

Détail du produit anti-Fatty Acid Synthase anticorps

Épitope: AA 9-202

Réactivité croisée: Chien, Souris, Lapin, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Fatty Acid Synthase aa. 9-202

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968587, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-Fatty Acid Synthase (ABIN968279)

Chirala, Huang, Jayakumar, Sakai, Wakil: "Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 11, pp. 5588-93, (1997) (PubMed).

Jayakumar, Tai, Huang, al-Feel, Hsu, Abu-Elheiga, Chirala, Wakil: "Human fatty acid synthase: properties and molecular cloning." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 19, pp. 8695-9, (1995) (PubMed).

Smith: "The animal fatty acid synthase: one gene, one polypeptide, seven enzymes." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 8, Issue 15, pp. 1248-59, (1995) (PubMed).

Détails sur Fatty Acid Synthase

Antigène: Fatty Acid Synthase (FASN)

Autre désignation: Fatty Acid Synthase

Sujet: Fatty acid biosynthesis occurs in all living organisms and provides essential components of biological membranes as well as a form of energy storage. Animal fatty acid synthase (FAS) is a multifunctional enzyme that catalyzes the synthesis of long-chain fatty acids via sequential condensation of two-carbon units from malonyl-CoA, an intermediate derived from the carboxylation of Acetyl-CoA. FAS is a homodimer of a multifunctional subunit protein that contains seven distinct activities and a site for the prosthetic group 4'-phosphopantetheine (acyl carrier protein). These domains are oriented from N-terminus to C-terminus as follows: beta-keto-acyl synthase, acetyl and malonyl transacylases, enoyl reductase, ketoacyl reductase, acyl carrier protein, and thioesterase. Although all domains are found on each subunit, they are only active following the homodimerization of subunits in an antiparallel (head-to-tail) orientation. This juxtaposition and cooperation between domains forms two centers for acyl chain assembly. Alternative substrates and chain-terminating mechanisms allow for the production of a variety of fatty acids with different lengths and structures.

Poids moléculaire: 265 kDa

Pathways: AMPK Signaling