STRAP anticorps (AA 42-154)

N° du produit ABIN968485

Cet anticorps Souris Monoclonal détecte spécifiquement STRAP dans WB et IF. Il présente une réactivité envers Humain et Rat et a été mentionné dans 1 publication.

Aperçu rapide pour STRAP anticorps (AA 42-154) (ABIN968485)

Antigène: STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STRAP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 22-STRAP

Détail du produit anti-STRAP anticorps

Épitope: AA 42-154

Réactivité croisée: Rat (Rattus), Humain

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse STRAP aa. 42-154

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968545, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-STRAP (ABIN968485)

Datta, Chytil, Gorska, Moses: "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling." dans: The Journal of biological chemistry, Vol. 273, Issue 52, pp. 34671-4, (1999) (PubMed).

Détails sur STRAP

Antigène: STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

Autre désignation: STRAP

Sujet: The transforming growth factor beta (TGF-beta) family of cytokines plays diverse and important roles in growth, development, and differentiation. Three high affinity TGF-beta receptor types have been characterized. Both type I and type II receptors are type I transmembrane proteins which contain a Ser/Thr-kinase in their cytosolic domains. Type III receptor, also known as betaglycan, has no cytosolic signaling motif and functions in the presentation of TGF-beta to the type I and type II receptors. The cytosolic domain kinase of the type I receptor is thought to be transphosphorylated by the corresponding kinase of the type II receptor, leading to activation of downstream substrates. Ser/Thr receptor associated protein (STRAP) contains six WD domains, which are characteristic of signal transduction proteins. STRAP can associate with both TGF-betaI and TGF-betaII receptors and overexpression of STRAP leads to inhibition of TGF-beta-dependent transcriptional activation. STRAP is expressed ubiquitously in species ranging from yeast to human. Thus, STRAP may be an important element of TGF-beta signal transduction pathways in a variety of tissues and species.

Poids moléculaire: 39 kDa