PAI1 anticorps (AA 207-329)

N° du produit ABIN968717

L’anticorps Souris Monoclonal anti-PAI1 a été validé pour WB et IF. Il convient pour détecter PAI1 dans des échantillons de Humain, Souris, Rat, Chien et Poulet. Il y a 3+ publications disponibles.

Aperçu rapide pour PAI1 anticorps (AA 207-329) (ABIN968717)

Antigène: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Reactivité: Humain, Souris, Rat, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAI1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 41-PAI

Détail du produit anti-PAI1 anticorps

Épitope: AA 207-329

Réactivité croisée: Chien, Rat (Rattus), Souris, Poulet

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human PAI-1 aa. 207-329

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-PAI1 (ABIN968717)

Cai, Li, Goette, Mera, Honeycutt, Feterik, Wilcox, Dudley, Harrison, Langberg: "Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke." dans: Circulation, Vol. 106, Issue 22, pp. 2854-8, (2002) (PubMed).

Bajou, Masson, Gerard, Schmitt, Albert, Praus, Lund, Frandsen, Brunner, Dano, Fusenig, Weidle, Carmeliet, Loskutoff, Collen, Carmeliet, Foidart, Noël: "The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies." dans: The Journal of cell biology, Vol. 152, Issue 4, pp. 777-84, (2001) (PubMed).

Ginsburg, Zeheb, Yang, Rafferty, Andreasen, Nielsen, Dano, Lebo, Gelehrter: "cDNA cloning of human plasminogen activator-inhibitor from endothelial cells." dans: The Journal of clinical investigation, Vol. 78, Issue 6, pp. 1673-80, (1986) (PubMed).

Détails sur PAI1

Antigène: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Autre désignation: PAI-1

Sujet: Fibrinolysis is regulated by the plasminogen activators, tissue plasminogen activator (tPA) and urokinase PA (uPA), and by the plasminogen activator-inhibitors (PAIs). Two PAIs include the serpin family members, PAI-1 and PAI-2. PAI-1 is a glycoprotein found in plasma, platelets, endothelial cells, hepatoma cells, and fibrosarcoma cells. Thrombin, endotoxin, and IL-1 induce PAI-1 synthesis in endothelial cells, which is where the major portion of plasma PAI-1 is produced. PAI-2 is a glycoprotein expressed in placenta and monocyte macrophages. The uPA/plasmin system may play a key role in cancer progression through degradation of the extracellular matrix during tumor cell migration. Paradoxically, high levels of PAI-1 are also predictive of poor prognosis of cancer patients. This finding may be a result of the role of plasmin proteolysis in the prevention of tumor vessel assembly. PAI-1 can promote tumor angiogenesis, and the mechanism may involve PAI-induced regulation of plasmin proteolysis during tumor angiogenesis. Thus, PAI-1 is a serpin protease inhibitor that is important for the regulation of plasmin proteolysis during fibrinolysis and extracellular matrix degradation.

Poids moléculaire: 47 kDa

Pathways: Signalisation p53, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration