TSG101 anticorps (AA 229-319)

N° du produit ABIN968912

L’anticorps Souris Monoclonal anti-TSG101 a été validé pour WB. Il convient pour détecter TSG101 dans des échantillons de Humain, Souris, Rat et Chien. Il y a 3+ publications disponibles.

Aperçu rapide pour TSG101 anticorps (AA 229-319) (ABIN968912)

Antigène: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TSG101 est non-conjugé

Application: Western Blotting (WB)

Clone: 51-TSG101

Détail du produit anti-TSG101 anticorps

Épitope: AA 229-319

Réactivité croisée: Souris, Rat (Rattus), Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human TSG101 aa. 229-319

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968586, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-TSG101 (ABIN968912)

Li, Liao, Ruland, Mak, Cohen: "A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 4, pp. 1619-24, (2001) (PubMed).

Zhong, Chen, Chen, Chen, Lee: "Identification of cellular TSG101 protein in multiple human breast cancer cell lines." dans: Cancer research, Vol. 57, Issue 19, pp. 4225-8, (1997) (PubMed).

Li, Cohen: "Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells." dans: Cell, Vol. 85, Issue 3, pp. 319-29, (1996) (PubMed).

Détails sur TSG101

Antigène: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Autre désignation: TSG101

Sujet: Tumor Susceptibility Gene 101 (TSG101) was identified in a random mutagenesis screen for potential tumor suppressors in NIH 3T3 cells. Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. Though the function of TSG101 is not clearly understood, its protein structure includes motifs involved in transcription regulation, and TSG101 has been shown to modulate the activation of steroid hormone receptors. In addition, TSG101 may have a role in regulating ubiquination. The N-terminal region of TSG101 contains a domain that resembles the catalytically active region of ubiquitin conjugases. However, TSG101 lacks an active-site cysteine crucial to the function of these conjugases. Interestingly, TSG101 interferes with MDM2 ubiquination leading to a decrease in MDM2 decay and down-regulation of p53 protein. Thus, TSG101 may function as a dominant-negative inhibitor of ubiquination in pathways where protein expression is tightly regulated.
Synonyms: Tumor Susceptibility Gene 101

Poids moléculaire: 46 kDa