APOB anticorps

N° du produit ABIN968961

Cet anticorps anti-APOB est un anticorps Souris Monoclonal détectant APOB dans ELISA, ICC et FACS. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour APOB anticorps (ABIN968961)

Antigène: APOB (Apolipoprotein B (APOB))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APOB est non-conjugé

Application: ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 6G6

Détail du produit anti-APOB anticorps

Fonction: ApoB Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human ApoB expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-APOB (ABIN968961)

Benn: "Apolipoprotein B levels, APOB alleles, and risk of ischemic cardiovascular disease in the general population, a review." dans: Atherosclerosis, Vol. 206, Issue 1, pp. 17-30, (2009) (PubMed).

Peterson, Mack, Hall, Alsup, Alexander, Sully, Sawires, Cheung, Otto, Gresham: "Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection." dans: Cell host & microbe, Vol. 4, Issue 6, pp. 555-66, (2008) (PubMed).

Détails sur APOB

Antigène: APOB (Apolipoprotein B (APOB))

Autre désignation: ApoB

Sujet: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.

Poids moléculaire: 516 kDa

ID gène: 338

UniProt: P04114

Pathways: Lipid Metabolism