CD40 anticorps

N° du produit ABIN969025

Cet anticorps Souris Monoclonal détecte spécifiquement CD40 dans ELISA et ICC. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour CD40 anticorps (ABIN969025)

Antigène: CD40

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD40 est non-conjugé

Application: ELISA, Immunocytochemistry (ICC)

Clone: 9G10

Détail du produit anti-CD40 anticorps

Fonction: CD40 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of CD40 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-CD40 (ABIN969025)

Linderoth, Jerkeman, Cavallin-Ståhl, Kvaløy, Torlakovic: "Immunohistochemical expression of CD23 and CD40 may identify prognostically favorable subgroups of diffuse large B-cell lymphoma: a Nordic Lymphoma Group Study." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 9, Issue 2, pp. 722-8, (2003) (PubMed).

Hakkarainen, Hemminki, Pereboev, Barker, Asiedu, Strong, Kanerva, Wahlfors, Curiel: "CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 9, Issue 2, pp. 619-24, (2003) (PubMed).

Détails sur CD40

Antigène: CD40

Autre désignation: CD40

Sujet: CD40 Molecule, TNF receptor superfamily member 5. It is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Poids moléculaire: 30.6 kDa

ID gène: 958

UniProt: P25942

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints