DKK1 anticorps

N° du produit ABIN969085

Cet anticorps Souris Monoclonal détecte spécifiquement DKK1 dans ELISA. Il présente une réactivité avec des échantillons de Humain. Il a été cité dans 2+ publications.

Aperçu rapide pour DKK1 anticorps (ABIN969085)

Antigène: DKK1 (Dickkopf Homolog 1 (DKK1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DKK1 est non-conjugé

Application: ELISA

Clone: 2H2

Détail du produit anti-DKK1 anticorps

Fonction: DKK1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of DKK1 expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-DKK1 (ABIN969085)

Yamamoto, Sakane, Yamamoto, Michiue, Kikuchi: "Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling." dans: Developmental cell, Vol. 15, Issue 1, pp. 37-48, (2008) (PubMed).

Qiao, Xu, Zhao, Ye, Zhang: "Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling." dans: Cancer letters, Vol. 269, Issue 1, pp. 67-77, (2008) (PubMed).

Détails sur DKK1

Antigène: DKK1 (Dickkopf Homolog 1 (DKK1))

Autre désignation: DKK1

Sujet: DKK1: dickkopf homolog 1 (Xenopus laevis), also known as SK. Entrez Protein NP_036374. DKK1 is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Poids moléculaire: 28.7 kDa

ID gène: 22943

UniProt: O94907

Pathways: Signalisation WNT, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation