EIF4E anticorps

N° du produit ABIN969094

Détail du produit anti-EIF4E anticorps

Antigène: EIF4E (Eukaryotic Translation Initiation Factor 4E (EIF4E))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EIF4E est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purification: purified

Immunogène: Purified recombinant fragment of human EIF4E expressed in E. coli.

Clone: 5D11

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-EIF4E (ABIN969094)

Slepenkov, Korneeva, Rhoads: "Kinetic mechanism for assembly of the m7GpppG.eIF4E.eIF4G complex." dans: The Journal of biological chemistry, Vol. 283, Issue 37, pp. 25227-37, (2008) (PubMed).

Holm, Byrnes, Johnson, Abreo, Sehon, Alley, Meschonat, Md, Li: "A prospective trial on initiation factor 4E (eIF4E) overexpression and cancer recurrence in node-negative breast cancer." dans: Annals of surgical oncology, Vol. 15, Issue 11, pp. 3207-15, (2008) (PubMed).

Détails sur EIF4E

Antigène: EIF4E (Eukaryotic Translation Initiation Factor 4E (EIF4E))

Autre désignation: EIF4E (EIF4E Produits)

Synonymes: anticorps AUTS19, anticorps CBP, anticorps EIF4E1, anticorps EIF4EL1, anticorps EIF4F, anticorps eif4e-1, anticorps zgc:86680, anticorps EG668879, anticorps Eif4e-ps, anticorps If4e, anticorps eIF-4E, anticorps 0260/09, anticorps 0587/11, anticorps 0589/11, anticorps 0919/12, anticorps 1004/13, anticorps 2, anticorps 7238, anticorps CG4035, anticorps CT13384, anticorps CT39424, anticorps CT39426, anticorps D-eIF4E, anticorps Dmel\\CG4035, anticorps Eif4E, anticorps Eif4e, anticorps IF4E, anticorps dEif4e, anticorps deIF-4E, anticorps deIF4E, anticorps eIF 4E, anticorps eIF-4E1, anticorps eIF-4E2, anticorps eIF-4EII, anticorps eIF-4e, anticorps eIF4E, anticorps eIF4E-1, anticorps eIF4E-1/2, anticorps eIF4E-2, anticorps eIF4E1, anticorps eIF4EI, anticorps eIF4e, anticorps eif-4E, anticorps eif-4e, anticorps eif4e, anticorps l(3)07238, anticorps l(3)67Af, anticorps l(3)S025007, anticorps l(3)S026009, anticorps l(3)S058711, anticorps l(3)S091912, anticorps cbp, anticorps eif4f, anticorps eif4e1, anticorps eif4el1, anticorps EIF-4E, anticorps zgc:101581, anticorps eukaryotic translation initiation factor 4E, anticorps eukaryotic translation initiation factor 4ea, anticorps Eukaryotic initiation factor 4E, anticorps eucaryotic initiation factor 6, anticorps eukaryotic translation initiation factor 4E L homeolog, anticorps eukaryotic translation initiation factor 4E family member 1B S homeolog, anticorps translation initiation factor eIF4E, anticorps eukaryotic translation initiation factor 4eb, anticorps EIF4E, anticorps eif4ea, anticorps Eif4e, anticorps eIF-4E, anticorps eif6, anticorps eif4e, anticorps eif4e.L, anticorps eif4e1b.S, anticorps LOC100533326, anticorps eif4eb

Sujet:

Description: eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk.

Aliases: CBP, EIF4F, EIF4E1, EIF4EL1, MGC111573, EIF4E

Poids moléculaire: 25 kDa

ID gène: 1977

HGNC: 1977

Pathways: BCR Signaling