EPH Receptor B4 anticorps

N° du produit ABIN969107

L’anticorps Souris Monoclonal anti-EPH Receptor B4 a été validé pour ELISA et IHC. Il convient pour détecter EPH Receptor B4 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour EPH Receptor B4 anticorps (ABIN969107)

Antigène: EPH Receptor B4 (EPHB4)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EPH Receptor B4 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Clone: 5B8F7

Détail du produit anti-EPH Receptor B4 anticorps

Fonction: EphB4 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of EphB4 expressed in E. Coli.

Isotype: IgG2a

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-EPH Receptor B4 (ABIN969107)

Chrencik, Brooun, Recht, Kraus, Koolpe, Kolatkar, Bruce, Martiny-Baron, Widmer, Pasquale, Kuhn: "Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity." dans: Structure (London, England : 1993), Vol. 14, Issue 2, pp. 321-30, (2006) (PubMed).

Wu, Suo, Risberg, Karlsson, Villman, Nesland: "Expression of Ephb2 and Ephb4 in breast carcinoma." dans: Pathology oncology research : POR, Vol. 10, Issue 1, pp. 26-33, (2004) (PubMed).

Détails sur EPH Receptor B4

Antigène: EPH Receptor B4 (EPHB4)

Autre désignation: EphB4

Sujet: EPH receptor B4 (EphB4), with 987-amino acid protein (about 108 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptor tyrosine kinases and their ligands, the ephrins, regulate numerous biological processes in developing and adult tissues and have been implicated in cancer progression and in pathological forms of angiogenesis. EphB4 acts as a negative regulator of blood vessel branching and vascular network formation, switching the vascularization program from sprouting angiogenesis to circumferential vessel growth. EphB4 and its ligand ephrinB2 express in several kinds of tumor cells and correlate with tumorigenesis. EphB4 is thus a potential candidate as a predictor of disease outcome in several kinds of tumor and as target for novel therapy.

UniProt: P54760

Pathways: Signalisation RTK