FOXP3 anticorps

N° du produit ABIN969156

Cet anticorps anti-FOXP3 est un anticorps Souris Monoclonal détectant FOXP3 dans ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour FOXP3 anticorps (ABIN969156)

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXP3 est non-conjugé

Application: ELISA

Clone: 4C7

Détail du produit anti-FOXP3 anticorps

Fonction: FOXP3 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human FOXP3 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-FOXP3 (ABIN969156)

Yuan, Chen, Li, Dong, Xue, Wang, Zhang, Wang, Zhang, Ge, Shen, Xu: "Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner." dans: Clinical immunology (Orlando, Fla.), Vol. 134, Issue 3, pp. 277-88, (2010) (PubMed).

Sarigul, Yazisiz, Bassorgun, Ulker, Avci, Erbasan, Gelen, Gorczynski, Terzioglu: "The numbers of Foxp3 + Treg cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjogren's syndrome." dans: Lupus, Vol. 19, Issue 2, pp. 138-45, (2010) (PubMed).

Détails sur FOXP3

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Autre désignation: FOXP3

Sujet: FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.

Poids moléculaire: 47.2 kDa

UniProt: Q9BZS1

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation