GSTM1 anticorps

N° du produit ABIN969180

Cet anticorps anti-GSTM1 est un anticorps Souris Monoclonal détectant GSTM1 dans WB, IHC, ELISA et FACS. Adapté pour Humain et Singe. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour GSTM1 anticorps (ABIN969180)

Antigène: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GSTM1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 1H4A4

Détail du produit anti-GSTM1 anticorps

Fonction: GSTM1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human GSTM1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-GSTM1 (ABIN969180)

Navarro, Peterson, Chen, Makar, Schwarz, King, Li, Li, Kestin, Lampe: "Cruciferous vegetable feeding alters UGT1A1 activity: diet- and genotype-dependent changes in serum bilirubin in a controlled feeding trial." dans: Cancer prevention research (Philadelphia, Pa.), Vol. 2, Issue 4, pp. 345-52, (2009) (PubMed).

Détails sur GSTM1

Antigène: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Autre désignation: GSTM1

Sujet: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

Poids moléculaire: 26 kDa

ID gène: 2944

UniProt: P09488

Pathways: Negative Regulation of Transporter Activity