USP7 anticorps

N° du produit ABIN969186

Cet anticorps anti-USP7 est un anticorps Souris Monoclonal détectant USP7 dans WB et ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour USP7 anticorps (ABIN969186)

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp USP7 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 5F11

Détail du produit anti-USP7 anticorps

Fonction: HAUSP Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human HAUSP expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-USP7 (ABIN969186)

Becker, Marchenko, Maurice, Moll: "Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma." dans: Cell death and differentiation, Vol. 14, Issue 7, pp. 1350-60, (2007) (PubMed).

Lu, Ma, Nguyen, Jones, Oren, Donehower: "The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop." dans: Cancer cell, Vol. 12, Issue 4, pp. 342-54, (2007) (PubMed).

Détails sur USP7

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Autre désignation: HAUSP

Sujet: USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.

Poids moléculaire: 128 kDa

ID gène: 7874

UniProt: Q93009