HDAC3 anticorps (AA 224-428)

N° du produit ABIN969188

L’anticorps Souris Monoclonal anti-HDAC3 a été validé pour WB, ELISA et ICC. Il convient pour détecter HDAC3 dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour HDAC3 anticorps (AA 224-428) (ABIN969188)

Antigène: HDAC3 (Histone Deacetylase 3 (HDAC3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HDAC3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Clone: 7G6C5

Détail du produit anti-HDAC3 anticorps

Épitope: AA 224-428

Fonction: HDAC3 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human HDAC3 (aa224-428) expressed in E. Coli.

Isotype: IgG2a

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-HDAC3 (ABIN969188)

Spurling, Godman, Noonan, Rasmussen, Rosenberg, Giardina: "HDAC3 overexpression and colon cancer cell proliferation and differentiation." dans: Molecular carcinogenesis, Vol. 47, Issue 2, pp. 137-47, (2008) (PubMed).

Grégoire, Xiao, Nie, Zhang, Xu, Li, Wong, Seto, Yang: "Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2." dans: Molecular and cellular biology, Vol. 27, Issue 4, pp. 1280-95, (2007) (PubMed).

Libý, Kostrouchová, Pohludka, Yilma, Hrabal, Sikora, Brozová, Kostrouchová, Rall, Kostrouch: "Elevated and deregulated expression of HDAC3 in human astrocytic glial tumours." dans: Folia biologica, Vol. 52, Issue 1-2, pp. 21-33, (2006) (PubMed).

Détails sur HDAC3

Antigène: HDAC3 (Histone Deacetylase 3 (HDAC3))

Autre désignation: HDAC3

Sujet: HDAC3: histone deacetylase 3, also known as HD3, RPD3, RPD3-2. Entrez Protein NC_000005. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Poids moléculaire: 48.8 kDa

ID gène: 8841

UniProt: O15379

Pathways: Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development