Hexokinase 1 anticorps

N° du produit ABIN969194

L’anticorps Souris Monoclonal anti-Hexokinase 1 a été validé pour WB, IHC, ELISA et ICC. Il convient pour détecter Hexokinase 1 dans des échantillons de Humain, Souris et Rat. Il y a 3+ publications disponibles.

Aperçu rapide pour Hexokinase 1 anticorps (ABIN969194)

Antigène: Hexokinase 1 (HK1)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Hexokinase 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Clone: 7A7

Détail du produit anti-Hexokinase 1 anticorps

Fonction: HK1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human HK1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Hexokinase 1 (ABIN969194)

Martins-de-Souza, Gattaz, Schmitt, Rewerts, Marangoni, Novello, Maccarrone, Turck, Dias-Neto: "Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis." dans: Journal of neural transmission (Vienna, Austria : 1996), Vol. 116, Issue 3, pp. 275-89, (2009) (PubMed).

Tsai: "Function of interdomain alpha-helix in human brain hexokinase: covalent linkage and catalytic regulation between N- and C-terminal halves." dans: Journal of biomedical science, Vol. 14, Issue 2, pp. 195-202, (2007) (PubMed).

Stelzl, Worm, Lalowski, Haenig, Brembeck, Goehler, Stroedicke, Zenkner, Schoenherr, Koeppen, Timm, Mintzlaff, Abraham, Bock, Kietzmann, Goedde, Toksöz, Droege, Krobitsch, Korn, Birchmeier, Lehrach et al.: "A human protein-protein interaction network: a resource for annotating the proteome. ..." dans: Cell, Vol. 122, Issue 6, pp. 957-68, (2005) (PubMed).

Détails sur Hexokinase 1

Antigène: Hexokinase 1 (HK1)

Autre désignation: HK1

Sujet: The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose- 6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases. HK I has been shown to be expressed in brain, kidney and heart tissues as well as in hepatoma cell lines.

Poids moléculaire: 102 kDa

UniProt: P19367

Pathways: Carbohydrate Homeostasis, L'effet Warburg