IL-2 anticorps

N° du produit ABIN969214

Détail du produit anti-IL-2 anticorps

Antigène: IL-2 (IL2) (Interleukin 2 (IL2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-2 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of IL2 expressed in E. coli.

Clone: 8D5

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-IL-2 (ABIN969214)

Das, Levine: "TGF-beta inhibits IL-2 production and promotes cell cycle arrest in TCR-activated effector/memory T cells in the presence of sustained TCR signal transduction." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 3, pp. 1490-8, (2008) (PubMed).

Lesniewski, Haviernik, Weitzel, Kadereit, Kozik, Fanning, Yang, Hegerfeldt, Finney, Ratajczak, Greco, Paul, Maciejewski, Laughlin: "Regulation of IL-2 expression by transcription factor BACH2 in umbilical cord blood CD4+ T cells." dans: Leukemia, Vol. 22, Issue 12, pp. 2201-7, (2008) (PubMed).

Détails sur IL-2

Antigène: IL-2 (IL2) (Interleukin 2 (IL2))

Autre désignation: IL-2 (IL2 Produits)

Synonymes: anticorps IL2, anticorps IL-2, anticorps il2, anticorps TCGF, anticorps lymphokine, anticorps Il-2, anticorps POIL2, anticorps interleukin 2, anticorps interleukin-15, anticorps IL2, anticorps il2, anticorps LOC100303688, anticorps Il2

Sujet:

Description: IL-2: interleukin-2. Entrez Protein NP_000577. It is a 17.6 kDa secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

Aliases: Aldesleukin, TCGF, interleukin-2

Poids moléculaire: 17.6 kDa

ID gène: 3558

HGNC: 3558

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation