ITK anticorps

N° du produit ABIN969222

Cet anticorps anti-ITK est un anticorps Souris Monoclonal détectant ITK dans WB, ELISA, ICC et FACS. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour ITK anticorps (ABIN969222)

Antigène: ITK (IL2-Inducible T-Cell Kinase (ITK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITK est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 5G6

Détail du produit anti-ITK anticorps

Fonction: ITK Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human ITK expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-ITK (ABIN969222)

Huck, Feyen, Niehues, Rüschendorf, Hübner, Laws, Telieps, Knapp, Wacker, Meindl, Jumaa, Borkhardt: "Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation." dans: The Journal of clinical investigation, Vol. 119, Issue 5, pp. 1350-8, (2009) (PubMed).

Kogina, Shoda, Yamaguchi, Tsuno, Takahashi, Fujio, Yamamoto: "Tacrolimus differentially regulates the proliferation of conventional and regulatory CD4(+) T cells." dans: Molecules and cells, Vol. 28, Issue 2, pp. 125-30, (2009) (PubMed).

Détails sur ITK

Antigène: ITK (IL2-Inducible T-Cell Kinase (ITK))

Autre désignation: ITK

Sujet: This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.

Poids moléculaire: 72 kDa

UniProt: Q08881

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway