PRKDC anticorps

N° du produit ABIN969366

Cité dans 2 publications. Cet anticorps anti-PRKDC Monoclonal Souris (Clone 3H6) (ABIN969366) détecte spécifiquement PRKDC dans IHC, ELISA et ICC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PRKDC anticorps (ABIN969366)

Antigène: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRKDC est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Clone: 3H6

Détail du produit anti-PRKDC anticorps

Fonction: PRKDC Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human PRKDC expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-PRKDC (ABIN969366)

Durkin, Guo, Fryrear, Mihaylova, Gupta, Belgnaoui, Haoudi, Kupfer, Semmes: "HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase." dans: The Journal of biological chemistry, Vol. 283, Issue 52, pp. 36311-20, (2008) (PubMed).

Huston, Lynch, Mohamed, Collins, Hill, MacLeod, Krause, Baillie, Houslay: "EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 35, pp. 12791-6, (2008) (PubMed).

Détails sur PRKDC

Antigène: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Autre désignation: PRKDC

Sujet: The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity, PRKDC must be bound to DNA to express its catalytic properties.

Poids moléculaire: 46.9 kDa

ID gène: 5591

UniProt: P78527

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response