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TYK2 anticorps

TYK2 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 8G8B3 unconjugated
N° du produit ABIN969448
  • Antigène Voir toutes TYK2 Anticorps
    TYK2 (Tyrosine Kinase 2 (TYK2))
    Reactivité
    • 78
    • 29
    • 22
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 73
    • 5
    Souris
    Clonalité
    • 73
    • 6
    Monoclonal
    Conjugué
    • 36
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp TYK2 est non-conjugé
    Application
    • 62
    • 37
    • 20
    • 13
    • 13
    • 13
    • 10
    • 6
    • 4
    • 2
    • 2
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogène
    Purified recombinant fragment of Tyk2 expressed in E. coli.
    Clone
    8G8B3
    Isotype
    IgG1
    Top Product
    Discover our top product TYK2 Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Shaw, Freeman, Scott, Fox, Bzik, Belkaid, Yap: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).

    Seto, Nakajima, Suto, Shimoda, Saito, Nakayama, Iwamoto: "Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1077-83, (2003) (PubMed).

  • Antigène
    TYK2 (Tyrosine Kinase 2 (TYK2))
    Autre désignation
    Tyk2 (TYK2 Produits)
    Synonymes
    anticorps JTK1, anticorps tyrosine kinase 2, anticorps TYK2, anticorps Tyk2
    Sujet

    Description: Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131 kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.

    Aliases: JTK1

    ID gène
    7297
    HGNC
    7297
    Pathways
    Signalistation JAK/STAT, Hepatitis C
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