TYRO3 anticorps

N° du produit ABIN969449

L’anticorps Souris Monoclonal anti-TYRO3 a été validé pour ELISA. Il convient pour détecter TYRO3 dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour TYRO3 anticorps (ABIN969449)

Antigène: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TYRO3 est non-conjugé

Application: ELISA

Clone: 10E11

Détail du produit anti-TYRO3 anticorps

Fonction: TYRO3 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant extracellular fragment of human TYRO3 fused with hIgGFc tag expressed in HEK293 cell line.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-TYRO3 (ABIN969449)

Lan, Wu, Li, Wu, Lu, Xu, Dai: "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway." dans: Blood, Vol. 95, Issue 2, pp. 633-8, (2000) (PubMed).

Détails sur TYRO3

Antigène: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Autre désignation: TYRO3

Sujet: TYRO3: Tyrosine-protein kinase, also known as BYK, Brt, Dtk, Sky. Entrez Protein: NP_006284. It belongs to the Tyr protein kinase family (AXL/UFO subfamily). The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse(also referred to as Tyro3 or Sky) and UFO (also called Tyro7 or Axl). Two distinct isoforms of Rse, designated Brt and Etk-2, have been described. Brt differs from Rse at its C-terminus, but more importantly lacks the N-terminal 31 amino acid signal peptide sequence present in Rse, which is replaced by a 27 amino acid Brt-specific sequence. It has been suggested that as a result of this alternative splicing event, Brt resides in the cytoplasm, unlike Rse which is expressed on the cell surface. Ekt-2 also lacks an N-terminal signal peptide which is substituted with a 45 amino acid Ekt-2-specific sequence. Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.

Poids moléculaire: 96.9 kDa

UniProt: Q06418

Pathways: Signalisation RTK