NK2 Homeobox 5 anticorps

N° du produit ABIN969487

Cet anticorps Souris Monoclonal détecte spécifiquement NK2 Homeobox 5 dans ELISA. Il présente une réactivité avec des échantillons de Humain. Il a été cité dans 2+ publications.

Aperçu rapide pour NK2 Homeobox 5 anticorps (ABIN969487)

Antigène: NK2 Homeobox 5 (NKX2-5)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NK2 Homeobox 5 est non-conjugé

Application: ELISA

Clone: 2E1

Détail du produit anti-NK2 Homeobox 5 anticorps

Fonction: NKX2.5 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human NKX2.5 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-NK2 Homeobox 5 (ABIN969487)

Brewer, Alexandrovich, Mjaatvedt, Shah, Patient, Pizzey: "GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis." dans: Stem cells and development, Vol. 14, Issue 4, pp. 425-39, (2005) (PubMed).

Ikeda, Hiroi, Hosoda, Utsunomiya, Matsuo, Ito, Inoue, Sumiyoshi, Takano, Nagai, Komuro: "Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease." dans: Circulation journal : official journal of the Japanese Circulation Society, Vol. 66, Issue 6, pp. 561-3, (2002) (PubMed).

Détails sur NK2 Homeobox 5

Antigène: NK2 Homeobox 5 (NKX2-5)

Autre désignation: NKX2.5

Sujet: NKX2.5: NK2 transcription factor related, locus 5 (Drosophila), also known as CSX. It is a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 35 kDa

ID gène: 1482

UniProt: P52952

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development