Hexosaminidase A anticorps

N° du produit ABIN969526

Cet anticorps Souris Monoclonal détecte spécifiquement Hexosaminidase A dans WB, ELISA et FACS. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour Hexosaminidase A anticorps (ABIN969526)

Antigène: Hexosaminidase A (HEXA)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Hexosaminidase A est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 3F10

Détail du produit anti-Hexosaminidase A anticorps

Fonction: HEXA Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human HEXA expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Hexosaminidase A (ABIN969526)

Park, Morgan, Sharma, Li, Lobo, Redman, Salazar, Sun, Neidich, Strom: "Improving accuracy of Tay Sachs carrier screening of the non-Jewish population: analysis of 34 carriers and six late-onset patients with HEXA enzyme and DNA sequence analysis." dans: Pediatric research, Vol. 67, Issue 2, pp. 217-20, (2010) (PubMed).

Olszewska, Borzym-Kluczyk, Rzewnicki, Rutkowska, Knas, Rogowski, Waniewska, Wielgosz: "Hexosaminidase as a new potential marker for larynx cancer." dans: Clinical biochemistry, Vol. 42, Issue 10-11, pp. 1187-9, (2009) (PubMed).

Détails sur Hexosaminidase A

Antigène: Hexosaminidase A (HEXA)

Autre désignation: HEXA

Sujet: This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).

Poids moléculaire: 60.7 kDa

UniProt: P06865

Pathways: Sensory Perception of Sound, Glycosaminoglycan Metabolic Process