PPM1A anticorps (AA 202-382)

N° du produit ABIN969556

Cet anticorps Souris Monoclonal détecte spécifiquement PPM1A dans WB, ELISA et FACS. Il présente une réactivité avec des échantillons de Humain et Singe. Il a été cité dans 2+ publications.

Aperçu rapide pour PPM1A anticorps (AA 202-382) (ABIN969556)

Antigène: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PPM1A est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 7F12H6

Détail du produit anti-PPM1A anticorps

Épitope: AA 202-382

Fonction: PPM1A Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-PPM1A (ABIN969556)

Malki, Uher, Paya-Cano, Binder, Rietschel, Zobel, Mors, Hauser, Henigsberg, Jerman, Souery, Placentino, Ng, Cohen-Woods, Sluyter, Farmer, Aitchison, Craig, Lewis, McGuffin, Schalkwyk: "Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." dans: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).

Sun, Yu, Dotti, Shen, Tan, Savoldo, Pass, Chu, Zhang, Lu, Fu, Lin, Yang: "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation." dans: Cellular signalling, Vol. 21, Issue 1, pp. 95-102, (2008) (PubMed).

Détails sur PPM1A

Antigène: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Autre désignation: PPM1A

Sujet: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Poids moléculaire: 42.4 kDa

ID gène: 5494

UniProt: P20265