PPM1A anticorps (AA 1-382)

N° du produit ABIN6146039

Détail du produit anti-PPM1A anticorps

Antigène: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Épitope: AA 1-382

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPM1A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ESWSFFAVYD GHAGSQVAKY CCEHLLDHIT NNQDFKGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPNAPKVSPE AVKKEAELDK YLECRVEEII KKQGEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA VYNRLNPYKN DDTDSTSTDD MW

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-382 of human PPM1A (NP_066283.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PPM1A

Antigène: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Autre désignation: PPM1A (PPM1A Produits)

Synonymes: anticorps PP2C-ALPHA, anticorps PP2CA, anticorps PP2Calpha, anticorps pp2ca1, anticorps ppp1r13b, anticorps si:ch211-253p18.1, anticorps wu:fd42g12, anticorps zgc:153820, anticorps 2310003C21Rik, anticorps 2900017D14Rik, anticorps AI427932, anticorps AU017636, anticorps MMPa-2, anticorps MPPa-1, anticorps Pp2c1, anticorps pp2c-alpha, anticorps pp2ca, anticorps pp2calpha, anticorps pp2ca2, anticorps protein phosphatase, Mg2+/Mn2+ dependent 1A, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1Ab, anticorps protein phosphatase 1A, magnesium dependent, alpha isoform, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1A, anticorps protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1Aa, anticorps PPM1A, anticorps ppm1ab, anticorps Ppm1a, anticorps ppm1a.L, anticorps ppm1aa

Sujet: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.,PPM1A,PP2C-ALPHA,PP2CA,PP2Calpha,Signal Transduction,PPM1A

Poids moléculaire: 35 kDa/42 kDa/51 kDa

ID gène: 5494

UniProt: P35813