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Axin Produits

(Axin 1 (AXIN1))
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010].

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Catégories Axin en vedette

Axin Anticorps

High quality antibodies with extensive validation data.

Axin Kits ELISA

Reliable ELISA kits for a wide range of species.

Axin Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

Axin recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC, ICC, FACS, Neut
Validations
  • (5)
N° du produit ABIN5611198
Quantité 0.1 mg
Fiche technique Fiche technique
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (4)
N° du produit ABIN7442327
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IF, PLA
Validations
  • (4)
N° du produit ABIN563582
Quantité 100 μg
Fiche technique Fiche technique

Axin recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965097
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN512400
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Cow
Analytical Method Quantitative
Validations
N° du produit ABIN989279
Quantité 96 tests
Fiche technique Fiche technique

Axin recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7121954
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1346237
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3089641
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits Axin

Cha, Cho, Lee, Lee, Jeong, Moon, Yun, Yang, Choi, Yoon, Kim, Kim, Kaduwal, Lee, Min, Kim, Han, Choi: "Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation." dans: Nature chemical biology, Vol. 12, Issue 8, pp. 593-600, (2016) (PubMed).

Shao, Wang, Zhong, Qi, Li: "AHSA1 regulates proliferation, apoptosis, migration, and invasion of osteosarcoma." dans: Biomedicine & pharmacotherapy, Vol. 77, pp. 45-51, (2016) (PubMed).

De Robertis, Mennillo, Rossi, Valensin, Tunici, Mori, Caradonna, Varrone, Salerno: "Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization." dans: PLoS ONE, Vol. 9, Issue 5, pp. e97847, (2014) (PubMed).

De Robertis, Valensin, Rossi, Tunici, Verani, De Rosa, Giordano, Varrone, Nencini, Pratelli, Benicchi, Bakker, Hill, Sangthongpitag, Pendharkar, Liu, Ng, Then, Jing Tai, Cheong, He, Caricasole et al.: "Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells. ..." dans: Molecular cancer therapeutics, Vol. 12, Issue 7, pp. 1180-9, (2013) (PubMed).

Weitzel, Illies, Byrum, Xu, Wikramanayake, Ettensohn: "Differential stability of beta-catenin along the animal-vegetal axis of the sea urchin embryo mediated by dishevelled." dans: Development (Cambridge, England), Vol. 131, Issue 12, pp. 2947-56, (2004) (PubMed).

Zeng, Fagotto, Zhang, Hsu, Vasicek, Perry, Lee, Tilghman, Gumbiner, Costantini: "The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation." dans: Cell, Vol. 90, Issue 1, pp. 181-92, (1997) (PubMed).

Synonymes et noms alternatifs relatifs à Axin

axin 1 (AXIN1), axin 1 S homeolog (axin1.S), axin 1 L homeolog (axin1.L), axin 1 (Axin1), axin 1 (axin1), AI316800, axin, AXIN, Axin, AXIN1, AXIN1-RGS, Fu, fused, Kb, Ki, kinky, knobbly, LOC100226467, PPP1R49, wu:fi22e03, wu:fj14c08, wu:fk11b03, xAxin, zgc:109872

Protein level used designations for Axin

  • axin 1
  • axin 1, isoform 1
  • axin-1-like
  • axin-1
  • xAxin
  • axis inhibition protein 1
  • axis inhibitor 1
  • fused, mouse, homolog of
  • protein phosphatase 1, regulatory subunit 49
  • protein Fused
  • GSK-3beta interacting protein rAxin
  • rAxin
  • masterblind
  • mbl
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