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B4GALT1 Produits

(UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1))
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose\; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008].

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Catégories B4GALT1 en vedette

B4GALT1 Anticorps

High quality antibodies with extensive validation data.

B4GALT1 Kits ELISA

Reliable ELISA kits for a wide range of species.

B4GALT1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

B4GALT1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application WB, ELISA, IHC, ICC, IF
Validations
  • (3)
N° du produit ABIN6259493
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, FACS
Validations
  • (2)
N° du produit ABIN652839
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (1)
N° du produit ABIN7180128
Quantité 100 μL
Fiche technique Fiche technique

B4GALT1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6971057
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6973484
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6960365
Quantité 96 tests
Fiche technique Fiche technique

B4GALT1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1346317
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
N° du produit ABIN7490703
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Human Cells
Validations
  • (1)
N° du produit ABIN7319810
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits B4GALT1

Stalder, Heusermann, Sokol, Trojer, Wirz, Hean, Fritzsche, Aeschimann, Pfanzagl, Basselet, Weiler, Hintersteiner, Morrissey, Meisner-Kober: "The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing." dans: The EMBO journal, Vol. 32, Issue 8, pp. 1115-27, (2013) (PubMed).

Synonymes et noms alternatifs relatifs à B4GALT1

beta-1,4-galactosyltransferase 1 (B4GALT1), UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1), beta-1,4-galactosyltransferase 1 (B4galt1), B-1,4-GalT, B-1,4-GalT1, B4GAL-T1, b4Gal-T1, beta-1,4-GalT, beta-1,4-GalT1, beta4Gal-T1, CDG2D, GalT, Ggtb, GGTB2, Ggtb2, GT1, GTB

Protein level used designations for B4GALT1

  • UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1
  • UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
  • beta-1,4-GalTase 1
  • beta-1,4-galactosyltransferase 1
  • glycoprotein-4-beta-galactosyltransferase 2
  • lactose synthase
  • b1,4-Galactosyltransferase I
  • galactosyltransferase 2 beta 1, 4
  • glycoprotein galactosyltransferase beta 1, 4
  • Glycoprotein-4-beta-galactosyltransferase 2
  • b4Gal-T1
  • beta4Gal-T1
  • beta-galactosyltransferase 2 (glycoprotein)
  • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
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