BRSK1 Produits
(BR Serine/threonine Kinase 1 (BRSK1))
Catégories
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV- induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
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Catégories BRSK1 en vedette
BRSK1 Anticorps
High quality antibodies with extensive validation data.
BRSK1 Kits ELISA
Reliable ELISA kits for a wide range of species.
BRSK1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
BRSK1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
N° du produit
ABIN7169019
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
N° du produit
ABIN652432
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB
Validations
- (3)
- (1)
N° du produit
ABIN1881121
Quantité
400 μL
Fiche technique
Fiche technique
BRSK1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN5648007
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN1157191
Quantité
96 tests
Fiche technique
Fiche technique
BRSK1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
N° du produit
ABIN5570636
Quantité
5 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346887
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3090446
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits BRSK1
: "Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 36, pp. 11938-50, (2010) (PubMed).: "SADB phosphorylation of gamma-tubulin regulates centrosome duplication." dans: Nature cell biology, Vol. 11, Issue 9, pp. 1081-92, (2009) (PubMed).
: "C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest." dans: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 77-84, (2008) (PubMed).
: "Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation." dans: The Journal of biological chemistry, Vol. 283, Issue 22, pp. 14946-54, (2008) (PubMed).
: "Mammalian SAD kinases are required for neuronal polarization." dans: Science (New York, N.Y.), Vol. 307, Issue 5711, pp. 929-32, (2005) (PubMed).
: "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function." dans: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31164-70, (2004) (PubMed).
: "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1." dans: The EMBO journal, Vol. 23, Issue 4, pp. 833-43, (2004) (PubMed).
Synonymes et noms alternatifs relatifs à BRSK1
BR serine/threonine kinase 1 (BRSK1), BR serine/threonine kinase 1 (Brsk1), BRSK1, Gm1100, hSAD1, RGD1563268, SAD-B, Sad-b, SADBProtein level used designations for BRSK1
- BR serine/threonine kinase 1
- BR serine/threonine-protein kinase 1-like
- BR serine/threonine-protein kinase 1
- SAD1 homolog
- SAD1 kinase
- SadB kinase short isoform
- brain-selective kinase 1
- brain-specific serine/threonine-protein kinase 1
- protein kinase SAD1A
- serine/threonine-protein kinase BRSK1
- serine/threonine-protein kinase SAD-B
- synapses of Amphids Defective homolog 1
- serine/threonine kinase SAD-B
- serine/threonine kinase SADB
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