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BTRC Produits

(beta-Transducin Repeat Containing (BTRC))
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class\; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012].

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Catégories BTRC en vedette

BTRC Anticorps

High quality antibodies with extensive validation data.

BTRC Kits ELISA

Reliable ELISA kits for a wide range of species.

BTRC Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

BTRC recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC, ICC, FACS, Neut
Validations
  • (7)
N° du produit ABIN5611131
Quantité 0.1 mg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (5)
N° du produit ABIN3022334
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IF, IHC (p)
Validations
  • (4)
N° du produit ABIN655814
Quantité 400 μL
Fiche technique Fiche technique

BTRC recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN1743134
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Sheep
Analytical Method
Validations
N° du produit ABIN1774039
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Dog
Analytical Method
Validations
N° du produit ABIN1769143
Quantité 96 tests
Fiche technique Fiche technique

BTRC recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1346979
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3092532
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3135065
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits BTRC

Lin, Chang, Lee, Campbell, Wang, Shen, Chung, Chang, Chiu, Pan, Lin, Chu, Kung, Cheng, Chang: "REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling." dans: Oncotarget, Vol. 7, Issue 18, pp. 26137-51, (2018) (PubMed).

Wan, Tang, Tytler, Lu, Jin, Vickers, Yang, Shi, Cao: "Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1." dans: The Journal of biological chemistry, Vol. 279, Issue 15, pp. 14484-7, (2004) (PubMed).

Zhou, Deng, Xia, Xu, Li, Gunduz, Hung: "Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition." dans: Nature cell biology, Vol. 6, Issue 10, pp. 931-40, (2004) (PubMed).

Busino, Donzelli, Chiesa, Guardavaccaro, Ganoth, Dorrello, Hershko, Pagano, Draetta: "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage." dans: Nature, Vol. 426, Issue 6962, pp. 87-91, (2003) (PubMed).

Yaron, Hatzubai, Davis, Lavon, Amit, Manning, Andersen, Mann, Mercurio, Ben-Neriah: "Identification of the receptor component of the IkappaBalpha-ubiquitin ligase." dans: Nature, Vol. 396, Issue 6711, pp. 590-4, (1999) (PubMed).

Margottin, Bour, Durand, Selig, Benichou, Richard, Thomas, Strebel, Benarous: "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif." dans: Molecular cell, Vol. 1, Issue 4, pp. 565-74, (1998) (PubMed).

Synonymes et noms alternatifs relatifs à BTRC

beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), beta-transducin repeat containing E3 ubiquitin protein ligase (btrc), beta-transducin repeat containing (btrc), beta-TrCP (LOC100634006), beta-transducin repeat containing E3 ubiquitin protein ligase (Btrc), beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog (btrc.S), beta-transducin repeat containing protein (Btrc), b-TrCP, Beta-TrCP, beta-TrCP, BETA-TRCP, beta-TrCP1, Beta-Trcp1, betaTrCP, BTRC, btrc, btrc-a, btrcp, bTrCP, btrcp1, bTrCP1, fbw1a, FBW1A, Fbw1a, fbxw1, FBXW1, fbxw1a, FBXW1A, fwd1, FWD1, HOS, mKIAA4123, Slimb

Protein level used designations for BTRC

  • beta-transducin repeat containing
  • beta-transducin repeat containing protein
  • F-box/WD repeat-containing protein 1A
  • f-box/WD repeat-containing protein 1A-like
  • E3RSIkappaB
  • F-box and WD repeats protein beta-TrCP
  • F-box and WD-repeat protein 1B
  • beta-TrCP1
  • epididymis tissue protein Li 2a
  • pIkappaBalpha-E3 receptor subunit
  • beta-TrCP
  • beta-transducin repeat-containing protein
  • SCF b-TRCP
  • beta-TrCP protein E3RS-IkappaB
  • mE3RS-IkappaB
  • pIkappaB-E3 receptor subunit
  • ubiquitin ligase FWD1
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