CARD8 Produits
(Caspase Recruitment Domain Family, Member 8 (CARD8))
Catégories
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].
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Catégories CARD8 en vedette
CARD8 Anticorps
High quality antibodies with extensive validation data.
CARD8 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CARD8 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
IHC, ELISA
Validations
- (2)
N° du produit
ABIN7146923
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IP
Validations
- (2)
N° du produit
ABIN524838
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, ICC
Validations
- (2)
N° du produit
ABIN2855381
Quantité
100 μL
Fiche technique
Fiche technique
CARD8 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6202321
Quantité
96 tests
Fiche technique
Fiche technique
CARD8 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1348057
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1348059
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1348061
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits CARD8
: "Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease." dans: The Journal of clinical investigation, Vol. 128, Issue 5, pp. 1793-1806, (2018) (PubMed).: "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis." dans: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13952-8, (2002) (PubMed).
: "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation." dans: FEBS letters, Vol. 521, Issue 1-3, pp. 165-9, (2002) (PubMed).
: "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer." dans: The Journal of biological chemistry, Vol. 276, Issue 34, pp. 32220-9, (2001) (PubMed).
: "DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis." dans: The Journal of cell biology, Vol. 151, Issue 3, pp. 495-506, (2000) (PubMed).
: "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)." dans: Immunity, Vol. 6, Issue 1, pp. 79-88, (1997) (PubMed).
: "LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 9, pp. 4615-9, (1997) (PubMed).
Synonymes et noms alternatifs relatifs à CARD8
caspase recruitment domain family, member 8 (CARD8), caspase recruitment domain-containing protein 8 (LOC718594), caspase recruitment domain family member 8 (CARD8), CARD8, CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCANProtein level used designations for CARD8
- caspase recruitment domain family, member 8
- CARD inhibitor of NF-kappaB-activating ligands
- apoptotic protein NDPP1
- caspase recruitment domain-containing protein 8
- tumor up-regulated CARD-containing antagonist of CASP9
- tumor up-regulated CARD-containing antagonist of caspase nine
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