This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008].
CTSD
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Dernières publications pour nos Cathepsin D Protéines
Redecker, Heckendorf, Grosch, Mersmann, Hasilik: "Molecular organization of the human cathepsin D gene." dans: DNA and cell biology, Vol. 10, Issue 6, pp. 423-31, (1991) (PubMed).
Westley, May: "Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells." dans: Nucleic acids research, Vol. 15, Issue 9, pp. 3773-86, (1987) (PubMed).
Faust, Kornfeld, Chirgwin: "Cloning and sequence analysis of cDNA for human cathepsin D." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 15, pp. 4910-4, (1985) (PubMed).
Pseudonymes pour Cathepsin D Protéines
cathepsin D (ctsd) Protéines cathepsin D (LOC398557) Protéines cathepsin D S homeolog (ctsd.S) Protéines cathepsin D (CatD) Protéines lysosomal aspartic protease (LOC5567565) Protéines cathepsin D (LOC100136761) Protéines cathepsin D (CTSD) Protéines cathepsin D (Cathd) Protéines cathepsin D (ctsD) Protéines cathepsin D (catd) Protéines cathepsin D (Ctsd) Protéines cathepsin D-like (LOC443060) Protéines catD Protéines CatD Protéines Cathd Protéines CD Protéines CLN10 Protéines CPSD Protéines CTSD Protéines DDBDRAFT_0205785 Protéines DDBDRAFT_0215012 Protéines DDB_0205785 Protéines DDB_0215012 Protéines DKFZp469J0315 Protéines fb93e11 Protéines fj17b09 Protéines LOC398557 Protéines LOC100136761 Protéines wu:fb93e11 Protéines wu:fj17b09 Protéines