The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
MET
Origine: Humain
Hôte: Mammalian Cells
Recombinant
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
MET
Origine: Humain
Hôte: Mammalian Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
MET
Origine: Cynomolgus
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
MET
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Yoo, Lee, Jung, Han, Lee, Han, Kim, Chae, Ryu, Chung: "Machine Learning-Guided Prediction of Antigen-Reactive In Silico Clonotypes Based on Changes in Clonal Abundance through Bio-Panning." dans: Biomolecules, Vol. 10, Issue 3, (2020) (PubMed).
Ma, Zhang, Wang, Huang, Kuai, Zhu, Chen, Jia, Feng, Tang, Liu: "High-Affinity Human Anti-c-Met IgG Conjugated to Oxaliplatin as Targeted Chemotherapy for Hepatocellular Carcinoma." dans: Frontiers in oncology, Vol. 9, pp. 717, (2019) (PubMed).
Wu, Zhou, Wang, Meng, Chen, Chang, Lee, Li, Li, Appelman, Kuick, Wang: "Detection of colonic neoplasia in vivo using near-infrared-labeled peptide targeting cMet." dans: Scientific reports, Vol. 9, Issue 1, pp. 17917, (2019) (PubMed).
Gong, Ren, Wu, Wu, Wu: "Fabs-in-tandem immunoglobulin is a novel and versatile bispecific design for engaging multiple therapeutic targets." dans: mAbs, Vol. 9, Issue 7, pp. 1118-1128, (2018) (PubMed).
Park, Kim, Kim, Sa, Lee, Yu, Oh, Kim, Yoon, Nam: "Tumor Inhibitory Effect of IRCR201, a Novel Cross-Reactive c-Met Antibody Targeting the PSI Domain." dans: International journal of molecular sciences, Vol. 18, Issue 9, (2018) (PubMed).
Li, Tavaré, Zettlitz, Mumenthaler, Mallick, Zhou, Marks, Wu: "Anti-MET immunoPET for non-small cell lung cancer using novel fully human antibody fragments." dans: Molecular cancer therapeutics, Vol. 13, Issue 11, pp. 2607-17, (2014) (PubMed).
Pseudonymes pour c-MET Protéines
MET proto-oncogene, receptor tyrosine kinase (MET) Protéines met proto-oncogene (Met) Protéines MET proto-oncogene, receptor tyrosine kinase (Met) Protéines MET proto-oncogene, receptor tyrosine kinase L homeolog (met.L) Protéines AI838057 Protéines AUTS9 Protéines c-Met Protéines c-met Protéines C-MET Protéines HGF Protéines HGFR Protéines Hgfr Protéines MET Protéines met Protéines met-A Protéines Par4 Protéines RCCP2 Protéines