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CD97 Produits

(CD97)

Catégories

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011].

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Catégories CD97 en vedette

CD97 Anticorps

High quality antibodies with extensive validation data.

CD97 Kits ELISA

Reliable ELISA kits for a wide range of species.

CD97 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

CD97 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, ELISA, FACS, ICC, Neut
Validations
  • (6)
N° du produit ABIN7193255
Quantité 0.1 mg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro)
Validations
  • (4)
N° du produit ABIN741495
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, RNAi
Validations
  • (4)
N° du produit ABIN560261
Quantité 100 μg
Fiche technique Fiche technique

CD97 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965617
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965616
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6720027
Quantité 1 kit
Fiche technique Fiche technique

CD97 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1348745
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1348744
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3091473
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits CD97

He, Xu, Feng, Wang: "Role of CD97 small isoform in human cervical carcinoma." dans: International journal of experimental pathology, Vol. 100, Issue 1, pp. 19-24, (2019) (PubMed).

Hovingh, van Gent, Hamstra, Demkes, Mooi, Pinelli: "Emerging Bordetella pertussis Strains Induce Enhanced Signaling of Human Pattern Recognition Receptors TLR2, NOD2 and Secretion of IL-10 by Dendritic Cells." dans: PLoS ONE, Vol. 12, Issue 1, pp. e0170027, (2017) (PubMed).

Zyryanova, Schneider, Adams, Sittig, Kerner, Gebhardt, Ruffert, Glasmacher, Hepp, Punkt, Neuhaus, Hamann, Aust: "Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function." dans: PLoS ONE, Vol. 9, Issue 6, pp. e100513, (2014) (PubMed).

Karpus, Veninga, Hoek, Flierman, van Buul, Vandenakker, vanBavel, Medof, van Lier, Reedquist, Hamann: "Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 7, pp. 3740-8, (2013) (PubMed).

Liu, Trojanowicz, Ye, Li, Zhang, Li, Li, Zheng, Chen: "The invasion and metastasis promotion role of CD97 small isoform in gastric carcinoma." dans: PLoS ONE, Vol. 7, Issue 6, pp. e39989, (2012) (PubMed).

Becker, Wandel, Wobus, Schneider, Amasheh, Sittig, Kerner, Naumann, Hamann, Aust: "Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions." dans: PLoS ONE, Vol. 5, Issue 1, pp. e8507, (2010) (PubMed).

Veninga, Becker, Hoek, Wobus, Wandel, van der Kaa, van der Valk, de Vos, Haase, Owens, van der Poll, van Lier, Verbeek, Aust, Hamann: "Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 9, pp. 6574-83, (2008) (PubMed).

Wang, Tian, Haino, Gao, Lake, Ward, Wang, Siebenlist, Murphy, Kelly: "Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97." dans: Infection and immunity, Vol. 75, Issue 3, pp. 1144-53, (2007) (PubMed).

Abbott, Spendlove, Roversi, Fitzgibbon, Knott, Teriete, McDonnell, Handford, Lea: "Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55." dans: The Journal of biological chemistry, Vol. 282, Issue 30, pp. 22023-32, (2007) (PubMed).

Galle, Sittig, Hanisch, Wobus, Wandel, Loeffler, Aust: "Individual cell-based models of tumor-environment interactions: Multiple effects of CD97 on tumor invasion." dans: The American journal of pathology, Vol. 169, Issue 5, pp. 1802-11, (2006) (PubMed).

Synonymes et noms alternatifs relatifs à CD97

adhesion G protein-coupled receptor E5 (Adgre5), adhesion G protein-coupled receptor E5 (ADGRE5), AA409984, TM7LN1

Protein level used designations for CD97

  • EGF-TM7 receptor
  • CD97 antigen
  • leukocyte antigen CD97
  • seven transmembrane helix receptor
  • seven-span transmembrane protein
  • seven-transmembrane, heterodimeric receptor associated with inflammation
  • CD97 large isoform
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