CSK Produits
(C-Src tyrosine Kinase (CSK))
Catégories
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
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Catégories CSK en vedette
CSK Anticorps
High quality antibodies with extensive validation data.
CSK Kits ELISA
Reliable ELISA kits for a wide range of species.
CSK Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CSK recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IP, IHC (p), RNAi
Validations
- (8)
N° du produit
ABIN560501
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC
Validations
- (4)
N° du produit
ABIN7101334
Quantité
20 μL
Fiche technique
Fiche technique
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, ELISA, ICC, FACS
Validations
- (3)
- (3)
N° du produit
ABIN969069
Quantité
100 μL
Fiche technique
Fiche technique
CSK recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6965267
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4886032
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380162
Quantité
2 x 96 tests
Fiche technique
Fiche technique
CSK recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1350517
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect cells (Sf9)
Validations
- (2)
N° du produit
ABIN5570539
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1350519
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits CSK
: "SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes." dans: PLoS ONE, Vol. 9, Issue 3, pp. e91582, (2014) (PubMed).: "Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase." dans: Scientific reports, Vol. 3, pp. 926, (2013) (PubMed).
: "Beta-catenin inhibits melanocyte migration but induces melanoma metastasis." dans: Oncogene, Vol. 32, Issue 17, pp. 2230-8, (2013) (PubMed).
: "Genome-wide association study of blood pressure and hypertension. ..." dans: Nature genetics, Vol. 41, Issue 6, pp. 677-87, (2010) (PubMed).
: "Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study." dans: Journal of hypertension, Vol. 29, Issue 1, pp. 62-9, (2010) (PubMed).
: "A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias." dans: Leukemia research, Vol. 33, Issue 9, pp. e168-9, (2009) (PubMed).
: "SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines." dans: The American journal of pathology, Vol. 170, Issue 1, pp. 366-76, (2007) (PubMed).
: "Functions of the activation loop in Csk protein-tyrosine kinase." dans: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 24072-7, (2003) (PubMed).
: "Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 9, pp. 4767-75, (2003) (PubMed).
: "Corneal IL-8 expression following adenovirus infection is mediated by c-Src activation in human corneal fibroblasts." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 6234-43, (2003) (PubMed).
Synonymes et noms alternatifs relatifs à CSK
C-terminal Src kinase (CSK), c-src tyrosine kinase (Csk), C-terminal Src kinase (Csk), c-src tyrosine kinase (CSK), CSK, non-receptor tyrosine kinase (CSK), AW212630Protein level used designations for CSK
- C-Src kinase
- protein-tyrosine kinase CYL
- tyrosine-protein kinase CSK
- p50CSK
- protein-tyrosine kinase MPK-2
- C-SRC kinase
- protein-tyrosine kinase (CSK)
- protein kinase
- src kinase
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