CTCF Protéines
(CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
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custom-made
CTCF
Origine: Souris
Hôte: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
CTCF
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
CTCF
Origine: Humain
Hôte: Wheat germ
Recombinant
ELISA, WB, AA, AP
1 image
1 reference
CTCF
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
Greater than 90 % as determined by SDS-PAGE.
ELISA, WB
1 image
CTCF
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTCF
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
> 95 % as determined by reducing SDS-PAGE.
custom-made
CTCF
Origine: Souris
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
custom-made
CTCF
Origine: Humain
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
Dernières publications pour nos CTCF Protéines
: "Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus." dans: PLoS ONE, Vol. 8, Issue 9, pp. e74956, (2013) (PubMed).: "CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing." dans: Nature, Vol. 479, Issue 7371, pp. 74-9, (2011) (PubMed).
: "CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop." dans: Molecular and cellular biology, Vol. 28, Issue 20, pp. 6473-82, (2008) (PubMed).
Pseudonymes pour CTCF Protéines
CCCTC-binding factor (CTCF) ProtéinesCCCTC-binding factor (zinc finger protein) (ctcf) Protéines
CCCTC-binding factor (ctcf) Protéines
CCCTC-binding factor (Ctcf) Protéines
AW108038 Protéines
CTCF Protéines
im:7152666 Protéines
xctcf Protéines
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