CTLA4 Protéines
(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].
| Catalog no. | Produit | Reactivité | Hôte / Clonalité | Application | Prix et délai de livraison |
|---|---|---|---|---|---|
| CTLA4 Protein (AA 36-161) (His tag,mFc Tag) | Humain | HEK-293 Cells |
|
974,62 €
Voir le prix
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| CTLA4 Protein (AA 36-161) (Biotin,His-Avi Tag) | Humain | HEK-293 Cells |
|
380,58 €
Voir le prix
|
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| CTLA4 Protein (AA 36-161) (Fc Tag) | Humain | HEK-293 Cells |
|
974,62 €
Voir le prix
|
|
| CTLA4 Protein (AA 37-160) (His tag) | Cynomolgus | HEK-293 Cells |
|
174,57 €
Voir le prix
|
|
| CTLA4 Protein (AA 37-161) (His tag) | Cobaye | Yeast (Pichia pastoris) |
|
287,60 €
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|
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| CTLA4 Protein (AA 37-161) (His-DYKDDDDK-Strep II Tag) | Humain | HEK-293T Cells |
|
952,00 €
Voir le prix
|
|
| CTLA4 Protein (AA 37-161) (His tag) | Souris | HEK-293 Cells |
|
203,60 €
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|
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| CTLA4 Protein (AA 36-162) (His tag) | Souris | HEK-293 Cells |
|
300,15 €
Voir le prix
|
|
| CTLA4 Protein (AA 37-162) (His tag) | Humain | HEK-293 Cells |
|
258,75 €
Voir le prix
|
|
| CTLA4 Protein (AA 37-162) (Fc Tag,AVI tag,Biotin) | Humain | HEK-293 Cells |
|
1.552,50 €
Voir le prix
|
|
| CTLA4 Protein (AA 36-162) (Fc Tag) | Souris | HEK-293 Cells |
|
817,38 €
Voir le prix
|
|
| CTLA4 Protéine | Humain | Escherichia coli (E. coli) |
|
777,84 €
Voir le prix
|
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| CTLA4 Protein (AA 1-161, Extracellular Domain) (His tag) | Rat | HEK-293 Cells |
|
746,00 €
Voir le prix
|
|
| CTLA4 Protein (AA 37-160) (Fc Tag) | Cynomolgus | HEK-293 Cells |
|
203,60 €
Voir le prix
|
|
| CTLA4 Protein (AA 36-135) (GST tag) | Humain | Wheat germ |
|
624,00 €
Voir le prix
|
|
| CTLA4 Protein (AA 37-161) (DYKDDDDK Tag) | Souris | HEK-293 Cells |
|
203,60 €
Voir le prix
|
|
| CTLA4 Protein (AA 36-162) (Fc Tag) | Souris | HEK-293 Cells |
|
300,15 €
Voir le prix
|
|
| CTLA4 Protein (AA 37-162) (Strep Tag) | Humain | HEK-293 Cells |
|
3.266,00 €
Voir le prix
|
|
| CTLA4 Protein (AA 37-160) (His tag,AVI tag,Biotin) | Cynomolgus, Macaque rhésus | HEK-293 Cells |
|
2.175,80 €
Voir le prix
|
|
| CTLA4 Protein (AA 37-160) (His tag) | Cynomolgus, Macaque rhésus | HEK-293 Cells |
|
300,15 €
Voir le prix
|
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- FACS (Flow Cytometry: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- AM (Affinity Measurement: Application indiquée)
- ADA (Antibody Drug Assay: Application indiquée)
- IA (Immunoassay: Application indiquée)
- ScA (Screening Assay: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- FACS (Flow Cytometry: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- AM (Affinity Measurement: Application indiquée)
- ADA (Antibody Drug Assay: Application indiquée)
- IA (Immunoassay: Application indiquée)
- ScA (Screening Assay: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: Image de validation disponible)
- SPR (Surface Plasmon Resonance: Image de validation disponible)
- Origine
- Cynomolgus
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- Activité biologique
- Active
Protein
- ELISA (ELISA: Image de validation disponible)
- WB (Western Blotting: Image de validation disponible)
- CC (Cell Culture: Application indiquée)
- Origine
- Cobaye
- Hôte
- Yeast (Pichia pastoris)
- Type Proteine
- Recombinant
- Pureté
- > 90 % as determined by reducing SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- WB (Western Blotting: Image de validation disponible)
- ELISA (ELISA: Application indiquée)
- PI (Protein Interaction: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293T Cells
- Type Proteine
- Recombinant
Protein
- ELISA (ELISA: Image de validation disponible)
- WB (Western Blotting: Image de validation disponible)
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Bind (Binding Studies: Image de validation disponible)
1 reference - Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Bind (Binding Studies: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Bind (Binding Studies: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by reduced SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- AM (Affinity Measurement: Application indiquée)
- ADA (Antibody Drug Assay: Application indiquée)
- IA (Immunoassay: Application indiquée)
- ScA (Screening Assay: Application indiquée)
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Origine
- Humain
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
Protein
- WB (Western Blotting: Image de validation disponible)
- Origine
- Rat
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- WB (Western Blotting: Image de validation disponible)
- Origine
- Cynomolgus
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- AP (Affinity Purification: Application indiquée)
- AA (Antibody Array: Application indiquée)
- ELISA (ELISA: Application indiquée)
- WB (Western Blotting: Application indiquée)
- Origine
- Humain
- Hôte
- Wheat germ
- Type Proteine
- Recombinant
Protein
- WB (Western Blotting: Image de validation disponible)
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Bind (Binding Studies: Image de validation disponible)
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Bind (Binding Studies: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- Origine
- Cynomolgus, Macaque rhésus
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- Origine
- Cynomolgus, Macaque rhésus
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
- Activité biologique
- Active
Dernières publications pour nos CTLA4 Protéines
: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." dans: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).
: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." dans: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).
: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." dans: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).
: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." dans: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).
: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." dans: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).
: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." dans: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).
: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." dans: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).
: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." dans: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).
: "Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens." dans: Cancer cell, Vol. 33, Issue 6, pp. 1033-1047.e5, (2019) (PubMed).
: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." dans: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).
: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." dans: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).
: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." dans: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).
: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." dans: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).
: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." dans: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).
: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." dans: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).
: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." dans: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).
: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." dans: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).
: "Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens." dans: Cancer cell, Vol. 33, Issue 6, pp. 1033-1047.e5, (2019) (PubMed).
: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." dans: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).
Pseudonymes pour CTLA4 Protéines
cytotoxic T-lymphocyte associated protein 4 (CTLA4) Protéinescytotoxic T-lymphocyte-associated protein 4 (Ctla4) Protéines
CD Protéines
CD152 Protéines
Cd152 Protéines
CELIAC3 Protéines
CTLA-4 Protéines
Ctla-4 Protéines
CTLA4 Protéines
GRD4 Protéines
GSE Protéines
IDDM12 Protéines
Ly-56 Protéines
sCTLA4 Protéines
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