DDR2 Produits
(Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))
Catégories
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
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Catégories DDR2 en vedette
DDR2 Anticorps
High quality antibodies with extensive validation data.
DDR2 Kits ELISA
Reliable ELISA kits for a wide range of species.
DDR2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
DDR2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (4)
N° du produit
ABIN392069
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, ICC
Validations
- (3)
- (3)
N° du produit
ABIN969083
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, FACS
Validations
- (5)
N° du produit
ABIN3030741
Quantité
0.4 mL
Fiche technique
Fiche technique
DDR2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966390
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955409
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4886342
Quantité
96 tests
Fiche technique
Fiche technique
DDR2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7274463
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7274461
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect cells (Sf9)
Validations
- (2)
N° du produit
ABIN5570020
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits DDR2
: "Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction." dans: Theranostics, Vol. 9, Issue 22, pp. 6550-6567, (2019) (PubMed).: "Targeting DDR2 in head and neck squamous cell carcinoma with dasatinib." dans: International journal of cancer, Vol. 139, Issue 10, pp. 2359-69, (2016) (PubMed).
: "NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4." dans: American journal of physiology. Heart and circulatory physiology, Vol. 309, Issue 9, pp. H1528-42, (2015) (PubMed).
: "NSCLC Driven by DDR2 Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy." dans: Molecular cancer therapeutics, Vol. 14, Issue 10, pp. 2382-9, (2015) (PubMed).
: "DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1." dans: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 101, (2015) (PubMed).
: "Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation." dans: Circulation research, Vol. 115, Issue 7, pp. 625-35, (2014) (PubMed).
: "Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts." dans: Biochemical pharmacology, Vol. 85, Issue 10, pp. 1486-94, (2013) (PubMed).
: "Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. ..." dans: Cancer discovery, Vol. 1, Issue 1, pp. 78-89, (2012) (PubMed).
: "The discoidin domain receptor DDR2 is a receptor for type X collagen." dans: Matrix biology : journal of the International Society for Matrix Biology, Vol. 25, Issue 6, pp. 355-64, (2006) (PubMed).
: "Regulation of discoidin domain receptor 2 by cyclic mechanical stretch in cultured rat vascular smooth muscle cells." dans: Hypertension, Vol. 46, Issue 3, pp. 614-21, (2005) (PubMed).
Synonymes et noms alternatifs relatifs à DDR2
discoidin domain receptor tyrosine kinase 2 (DDR2), discoidin domain receptor family, member 2 (Ddr2), discoidin domain receptor tyrosine kinase 2 (Ddr2), discoidin domain receptor family, member 2, like (ddr2l), AW495251, DDR2, ddr2, MIG20a, NTRKR3, Ntrkr3, si:ch211-193c2.1, TKT, TYRO10, tyro10, Tyro10Protein level used designations for DDR2
- CD167 antigen-like family member B
- cell migration-inducing protein 20
- discoidin domain receptor 2
- discoidin domain receptor family, member 2
- discoidin domain-containing receptor 2
- discoidin domain-containing receptor tyrosine kinase 2
- hydroxyaryl-protein kinase
- migration-inducing gene 16 protein
- neurotrophic tyrosine kinase receptor related 3
- neurotrophic tyrosine kinase, receptor-related 3
- receptor protein-tyrosine kinase TKT
- tyrosine-protein kinase TYRO10
- tyrosylprotein kinase
- discoidin domain receptor tyrosine kinase 2
- CD167b antigen
- tyrosine-protein kinase TYRO 10
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