DUSP6 Produits
(Dual Specificity Phosphatase 6 (DUSP6))
Catégories
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Catégories DUSP6 en vedette
DUSP6 Anticorps
High quality antibodies with extensive validation data.
DUSP6 Kits ELISA
Reliable ELISA kits for a wide range of species.
DUSP6 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
DUSP6 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), RNAi
Validations
- (3)
- (6)
N° du produit
ABIN560670
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IF, IHC (p)
Validations
- (6)
N° du produit
ABIN392864
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (5)
N° du produit
ABIN7436195
Quantité
100 μL
Fiche technique
Fiche technique
DUSP6 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955468
Quantité
96 tests
Fiche technique
Fiche technique
DUSP6 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122714
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1352140
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3079239
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits DUSP6
: "Hepatitis C virus-induced reduction in miR-181a impairs CD4(+) T-cell responses through overexpression of DUSP6." dans: Hepatology (Baltimore, Md.), (2015) (PubMed).: "TSH signaling overcomes B-RafV600E-induced senescence in papillary thyroid carcinogenesis through regulation of DUSP6." dans: Neoplasia (New York, N.Y.), Vol. 16, Issue 12, pp. 1107-20, (2014) (PubMed).
: "Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML." dans: The Journal of experimental medicine, Vol. 211, Issue 6, pp. 1093-108, (2014) (PubMed).
: "Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer." dans: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 167, Issue 1, pp. 93-101, (2012) (PubMed).
: "Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of ..." dans: The Journal of biological chemistry, Vol. 286, Issue 29, pp. 25663-74, (2011) (PubMed).
: "Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis." dans: The American journal of pathology, Vol. 175, Issue 2, pp. 867-81, (2009) (PubMed).
: "Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart." dans: American journal of physiology. Heart and circulatory physiology, Vol. 290, Issue 4, pp. H1587-95, (2006) (PubMed).
: "Abrogation of DUSP6 by hypermethylation in human pancreatic cancer." dans: Journal of human genetics, Vol. 50, Issue 4, pp. 159-67, (2005) (PubMed).
: "Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas." dans: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 18, Issue 8, pp. 1034-42, (2005) (PubMed).
: "Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal." dans: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 41882-91, (2004) (PubMed).
Synonymes et noms alternatifs relatifs à DUSP6
dual specificity phosphatase 6 (DUSP6), dual specificity phosphatase 6 (Dusp6), dual specificity phosphatase 6 (dusp6), dual specificity phosphatase 6 L homeolog (dusp6.L), Dual specificity protein phosphatase 6 (dus6), 1300019I03Rik, DUSP6, dusp6, HH19, MKP-3, MKP3, Mkp3, mkp3, PYST1, pyst1, wu:fd99d09Protein level used designations for DUSP6
- MAP kinase phosphatase 3
- dual specificity protein phosphatase 6
- dual specificity protein phosphatase PYST1
- mitogen-activated protein kinase phosphatase 3
- serine/threonine specific protein phosphatase
- MKP-3
- etID14116.25
- MAP kinase phosphatase X17C
- dual specificity phosphatase 6
- Dual specificity protein phosphatase 6
- dual specificity protein phosphatase 6-like
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