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FZR1 Produits

(Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Catégories

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity).

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Catégories FZR1 en vedette

FZR1 Anticorps

High quality antibodies with extensive validation data.

FZR1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

FZR1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p), PLA
Validations
  • (5)
N° du produit ABIN526652
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (1)
  • (5)
N° du produit ABIN2784494
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
  • (3)
N° du produit ABIN1714172
Quantité 100 μL
Fiche technique Fiche technique

FZR1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1133421
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1133422
Quantité 96 tests
Fiche technique Fiche technique

FZR1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1354595
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1354593
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3092674
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits FZR1

Li, Zhang, Yao, Zhang, Wan, Zhang: "APC-Cdh1 Regulates Neuronal Apoptosis Through Modulating Glycolysis and Pentose-Phosphate Pathway After Oxygen-Glucose Deprivation and Reperfusion." dans: Cellular and molecular neurobiology, Vol. 39, Issue 1, pp. 123-135, (2019) (PubMed).

Kim, Cho, Wang, Park, Ma, Kim, Gan, Jho, Cha, Jeung, Zhang, Gao, Wei, Jiang, Chung, Yang: "Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 19, pp. 9423-9432, (2019) (PubMed).

Yang, Jin, Fan, Liang, Jia, Tan, Huang, Li, Ma, Li: "Inhibition of neddylation causes meiotic arrest in mouse oocyte." dans: Cell cycle (Georgetown, Tex.), Vol. 18, Issue 11, pp. 1254-1267, (2019) (PubMed).

Giráldez, Galindo-Moreno, Limón-Mortés, Rivas, Herrero-Ruiz, Mora-Santos, Sáez, Japón, Tortolero, Romero: "G1/S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 31, Issue 7, pp. 2925-2936, (2017) (PubMed).

Fuchsberger, Martínez-Bellver, Giraldo, Teruel-Martí, Lloret, Viña: "Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival." dans: Scientific reports, Vol. 6, pp. 31158, (2016) (PubMed).

Hu, Li, Li, Tan, Wan, Zhu, Zhang, Zhang, Yao: "Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats." dans: Molecular pain, Vol. 12, (2016) (PubMed).

Yamamoto, Takano, Ishiwata, Ohmura, Nagahata, Matsuura, Kamata, Sakamoto, Nakanishi, Kubo, Hishiki, Suematsu: "Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway." dans: Nature communications, Vol. 5, pp. 3480, (2014) (PubMed).

Synonymes et noms alternatifs relatifs à FZR1

fizzy and cell division cycle 20 related 1 (Fzr1), fizzy/cell division cycle 20 related 1 (CDH1-C), fizzy and cell division cycle 20 related 1 (FZR1), fizzy-related protein homolog (LOC100027495), fizzy-related protein homolog (LOC100179951), fizzy/cell division cycle 20 related 1 (Drosophila) (Fzr1), fizzy/cell division cycle 20 related 1a (fzr1a), AW108046, CDC20C, CDH1, Cdh1, CDH1-C, FYR, Fyr, FZR, fzr1, FZR2, HCDH, HCDH1, zgc:55450

Protein level used designations for FZR1

  • fizzy-related protein homolog
  • fizzy/cell division cycle 20 related 1 (Drosophila)
  • fizzy-related protein FZR
  • Fizzy-related protein-like protein
  • fizzy/cell division cycle 20 related 1
  • CDC20-like 1b
  • CDC20-like protein 1
  • cdh1/Hct1 homolog
  • cell division cycle 20 related 1
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